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Correspondence 0001213900-25-126780 from Cadrenal Therapeutics, Inc. (CVKD)

Cadrenal Therapeutics, Inc.
Date: Dec. 30, 2025 · CIK: 0001937993 · Accession: 0001213900-25-126780

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File numbers found in text: 333-292444

Date
December 29, 2025
Author
Quang X. Pham
Form
CORRESP
Company
Cadrenal Therapeutics, Inc.

Letter

VIA EDGAR United States Securities Division of Corporation Finance Attention: Tim Buchmiller Re: Cadrenal Therapeutics, Inc. Registration Statement on Form S-1 Filed December 29, 2025 File No: 333-292444

Dear Mr. Buchmiller:

Cadrenal Therapeutics, Inc. (the " Registrant ") hereby requests that the effective date of the above-referenced Registration Statement on Form S-3 (File No. 333-292444), be accelerated by the U.S. Securities and Exchange Commission (the " Commission ") to become effective on Wednesday, December 31, 2025 , at 4:00 p.m ., Eastern Time, or as soon as reasonably practicable thereafter.

The Registrant understands that the Staff of the Commission will consider this request as confirmation by the Registrant that it is aware of its responsibilities under the federal securities laws as they relate to the issuance of the securities covered by the Registration Statement.

The Registrant hereby authorizes Leslie Marlow and/or Jamie Plisner of Blank Rome LLP to orally modify or withdraw this request for acceleration. Please contact Ms. Marlow at (212) 885-5358 or Ms. Plisner at (212) 885-5298 with any questions you may have concerning this request, and please notify either of them when this request for acceleration has been granted.

Thank you.

Very truly yours,
CADRENAL THERAPEUTICS, INC.

Show Raw Text
CORRESP
 1
 filename1.htm

 December
30, 2025

 VIA
EDGAR

 United
States Securities

 and
Exchange Commission

 Division
of Corporation Finance

 100
F Street, N.E.

 Washington,
D.C. 20549

 Attention:
Tim Buchmiller

 Re:
 Cadrenal Therapeutics, Inc.

 Registration Statement on Form S-1

 Filed
 December 29, 2025
 File
 No: 333-292444

 Dear
Mr. Buchmiller:

 Cadrenal
Therapeutics, Inc. (the " Registrant ") hereby requests that the effective date of the above-referenced Registration
Statement on Form S-3 (File No. 333-292444), be accelerated by the U.S. Securities and Exchange Commission (the " Commission ")
to become effective on Wednesday, December 31, 2025 , at 4:00 p.m ., Eastern Time, or as soon as reasonably practicable thereafter.

 The
Registrant understands that the Staff of the Commission will consider this request as confirmation by the Registrant that it is aware
of its responsibilities under the federal securities laws as they relate to the issuance of the securities covered by the Registration
Statement.

 The
Registrant hereby authorizes Leslie Marlow and/or Jamie Plisner of Blank Rome LLP to orally modify or withdraw this request for acceleration.
Please contact Ms. Marlow at (212) 885-5358 or Ms. Plisner at (212) 885-5298 with any questions you may have concerning this request,
and please notify either of them when this request for acceleration has been granted.

 Thank
you.

 Very truly yours,

 CADRENAL THERAPEUTICS, INC.

 By:
 /s/
 Quang X. Pham

 Name:
 Quang X.
 Pham

 Title:
 Chief Executive Officer

 cc:
 Leslie Marlow, Blank Rome LLP

 Jamie
Plisner, Blank Rome LLP