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CORRESP Filing

Cadrenal Therapeutics, Inc.
Date: April 27, 2026 · CIK: 0001937993 · Accession: 0001213900-26-048169

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File numbers found in text: 333-295200

Date
April 27, 2026
Author
Quang Pham
Form
CORRESP
Company
Cadrenal Therapeutics, Inc.

Letter

VIA EDGAR United States Securities Division of Corporation Finance Attention: Alan Campbell Re: Cadrenal Therapeutics, Inc. Registration Statement on Form S-1 Filed April 21, 2026 File No: 333-295200

Dear Mr. Campbell:

Cadrenal Therapeutics, Inc. (the “Registrant”) hereby requests that the effective date of the above-referenced Registration Statement on Form S-3 (File No. 333-295200), be accelerated by the U.S. Securities and Exchange Commission (the “Commission”) to become effective on Wednesday, April 29, 2026, at 5:00 p.m., Eastern Time, or as soon as reasonably practicable thereafter.

The Registrant understands that the Staff of the Commission will consider this request as confirmation by the Registrant that it is aware of its responsibilities under the federal securities laws as they relate to the issuance of the securities covered by the Registration Statement.

The Registrant hereby authorizes Leslie Marlow and/or Jamie Plisner of Blank Rome LLP to orally modify or withdraw this request for acceleration. Please contact Ms. Marlow at (212) 885-5358 or Ms. Plisner at (212) 885-5298 with any questions you may have concerning this request, and please notify either of them when this request for acceleration has been granted.

Thank you.

Very truly yours,
CADRENAL THERAPEUTICS, INC.

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CORRESP
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filename1.htm

April 27, 2026

VIA EDGAR

United States Securities

and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Alan Campbell

    Re:
    Cadrenal Therapeutics, Inc.

    Registration Statement on Form S-1

    Filed April 21, 2026

    File No: 333-295200

Dear Mr. Campbell:

Cadrenal Therapeutics, Inc.
(the “Registrant”) hereby requests that the effective date of the above-referenced Registration Statement on Form S-3
(File No. 333-295200), be accelerated by the U.S. Securities and Exchange Commission (the “Commission”) to become effective
on Wednesday, April 29, 2026, at 5:00 p.m., Eastern Time, or as soon as reasonably practicable thereafter.

The Registrant understands
that the Staff of the Commission will consider this request as confirmation by the Registrant that it is aware of its responsibilities
under the federal securities laws as they relate to the issuance of the securities covered by the Registration Statement.

The Registrant hereby authorizes
Leslie Marlow and/or Jamie Plisner of Blank Rome LLP to orally modify or withdraw this request for acceleration. Please contact Ms. Marlow
at (212) 885-5358 or Ms. Plisner at (212) 885-5298 with any questions you may have concerning this request, and please notify either of
them when this request for acceleration has been granted.

Thank you.

    Very truly yours,

    CADRENAL THERAPEUTICS, INC.

    By:
    /s/ Quang Pham

    Name:
    Quang Pham

    Title:
    Chief Executive Officer

cc: Leslie Marlow, Blank Rome LLP

  Jamie Plisner, Blank Rome LLP