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60 Degrees Pharmaceuticals, Inc.

1025 Connecticut
Avenue NW, Suite 1000

Washington,
DC 20036

July 16, 2024

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

 Re: 60 Degrees Pharmaceuticals, Inc. Request for Acceleration

 Registration Statement on Form S-3

 File No. 333-280796

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities
Act of 1933, as amended (the “Securities Act”), 60 Degrees Pharmaceuticals, Inc., a Delaware corporation (the “Company”),
respectfully requests that the effective date of its Registration Statement on Form S-3 (File No. 333-280796)
(the “Registration Statement”), be accelerated so that it will become effective at 9:00 a.m., Eastern Time, on July 18, 2024
or as soon thereafter as possible.

In making this acceleration request, the Company
acknowledges that:

 (i) should the Securities and Exchange
Commission (the “Commission”) or the staff, acting pursuant to delegated authority, declare the Registration Statement effective,
it does not foreclose the Commission from taking any action with respect to the Registration Statement;

 (ii) the action of the Commission
or the staff, acting pursuant to delegated authority, in declaring the Registration Statement effective, does not relieve the Company
from its full responsibility for the adequacy of the disclosure in the Registration Statement; and

 (iii) the Company may not assert
comments of the Commission or the staff and the declaration of effectiveness of the Registration Statement as a defense in any proceeding
initiated by the Commission or any person under the federal securities laws of the United States.

Once the Registration Statement is effective,
please orally confirm the event with our counsel, Sichenzia Ross Ference Carmel LLP by calling Philip
Magri at (646) 661-5203. We also respectfully request that a copy of the written order from the Commission verifying the effective
time and date of the Registration Statement be sent to our counsel, Sichenzia Ross Ference Carmel LLP, Attention: Philip
Magri, by facsimile to (212) 930-9725 or email at PMagri@SRFC.LAW.

If you have any questions regarding this request,
please contact Philip Magri of Sichenzia Ross Ference Carmel LLP at (646) 661-5203.

    Very truly yours,

    By:
    /s/ Geoffrey Dow

    Name:
    Geoffrey Dow

    Title:
    Chief Executive Officer and President

 cc: Philip Magri, Sichenzia
Ross Ference Carmel LLP