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            Gibson, Dunn & Crutcher LLP

            One Embarcadero Center, Suite 2600

            San Francisco, CA 94111-3715 www.gibsondunn.com

            Ryan Murr

            Direct: +1 415.393.8373

            Mobile: +1 858.232.0349

            RMurr@gibsondunn.com

    VIA ELECTRONIC MAIL AND EDGAR FILING

    United States Securities and Exchange Commission

    Division of Corporation Finance

    Office of Mergers and Acquisitions

    100 F Street NE

    Washington, D.C. 20549

    Attention: Mr. Daniel Duchovny

    August 15, 2025

            Re:

            iTeos Therapeutics, Inc.

            Schedule TO-T filed by Concentra Biosciences, LLC, Concentra Merger Sub

            VIII, Inc., Tang Capital Partners, LP, and Tang Capital Management, LLC

            Filed August 1, 2025

            File No. 005-91596

    Dear Mr. Duchovny:

    On behalf of Concentra Biosciences, LLC (“Parent”), Concentra Merger Sub VIII, Inc. (“Merger Sub”, and collectively with Parent, Tang Capital Partners, LP and Tang Capital Management,
      LLC, the “Co-Offerors”), please find responses to comments received from the staff of the Division of Corporation Finance (the “Staff”) of the Securities and Exchange Commission (the “Commission”) by letter dated August 8, 2025
      (“Letter”), with respect to its Schedule TO-T originally filed on August 1, 2025 (the “Schedule TO”) and the Offer to Purchase, dated August 1, 2025 (the “Offer to Purchase” and, together with the Schedule TO, the “Tender
        Offer Materials”). Concurrently with delivery of this letter, the Co-Offerors have filed an amendment to the Schedule TO-T (the “Schedule TO Amendment”), which reflects revisions to address the Staff’s comments.

    For your convenience, we have restated below in bold each comment from the Letter and supplied our responses immediately thereafter. Unless otherwise specified, all references to page numbers and
      captions correspond to the Schedule TO Amendment and all capitalized terms used but not defined herein have the same meaning as in the Tender Offer Materials.

    Schedule TO-T

          1.

            We note that the merger agreement, filed as exhibit (d)(1) to this Schedule TO, refers, in section 2.01(c) to a Schedule I. We also note that such schedule does not appear to have been filed. Please file the
              schedule or advise.

    Response: In response to the Staff’s comment, the Co-Offerors have filed a Schedule TO Amendment and included
      Schedule I in the Merger Agreement filed as Exhibit (d)(1) to the Schedule TO Amendment. As described in Section 2.01(c)(ii) of the Merger Agreement, Schedule I was attached for illustrative purposes only to show how Closing Net Cash is calculated.
      Thus, the Co-Offers have redacted the illustrative numbers used in such Schedule.

      -1-

          2.

            We note the repeated use of the term “certain” in your description of the terms of the Limited Guaranty. Please revise your disclosure to provide additional details such that security holders are able to
              ascertain the terms of the guaranty.

    Response: In response to the Staff’s comment, the Co-Offerors have revised the disclosures regarding the Limited Guaranty in the Schedule TO Amendment to add
      the following underlined language and remove the following strikethrough language to the third paragraph of the cover page and the third paragraph of the “Summary Term Sheet” on page 1 of the Offer to Purchase. The Co-Offerors have also made
      conforming edits to the “Introduction” on page 13 and to “—7. Summary of the Merger Agreement and Certain Other Agreements” on page 47 of the Offer to Purchase.

    Concurrently with the execution of the Merger Agreement, and as a condition and inducement to iTeos’ willingness to enter into the Merger Agreement and the CVR
          Agreement, Tang Capital Partners, LP, a Delaware limited partnership (“TCP” or “Guarantor”) and sole member of Parent, delivered to iTeos a duly executed limited guaranty (the “Limited Guaranty”), dated as of the
      date of the Merger Agreement, in favor of iTeos and the Representative representative of the holders of the CVRs (the “Representative”) to be that will be a party to the CVR Agreement (the “Representative”), in respect of certain
          obligations of Parent and Merger Sub under the Merger Agreement and the CVR Agreement. Certain obligations under the Limited Guaranty are subject to a cap of $465,000,000, which includes certain Enforcement Costs, under the Merger Agreement and
          an amount equivalent to the CVR Proceeds (as defined below), plus certain Enforcement Costs up to the CVR Expense Cap, under the CVR Agreement. the obligations of Parent and Merger Sub with
          respect to (i) the prompt payment of all amounts payable by Parent and/or Merger Sub under the Merger Agreement, (ii) the payment of monetary damages in connection with fraud or willful breach by Parent or Merger Sub pursuant to a final
          non-appealable judgment by a court of competent jurisdiction (and related enforcement costs), and (iii) the payment obligations and performance of the covenants of Parent and Merger Sub set forth in the CVR Agreement, including to pay (A) amounts
          due thereunder and (B) any costs and expenses incurred in connection with enforcing the Merger Agreement by legal action against Parent or Merger Sub for willful breach to the extent such enforcement actions result in a judgment against Parent or
          Merger Sub. The Guarantor’s obligations with respect to items (i) and (ii) described above are subject to a cap of $465,000,000. The Guarantor’s obligations with respect to item (iii)(A) described above are subject to a cap equal to the aggregate
          CVR Proceeds (as defined below) and the Guarantor’s obligations with respect to item (iii)(B) described above are subject to a cap equal to the CVR Expense Cap. Tang Capital Management, LLC, a Delaware limited liability company (“TCM”),
      is the sole manager of Parent and the general partner of TCP. Accordingly, TCP and TCM are considered co-offerors in the Offer. As co-offerors, TCP and TCM accept joint responsibility for the accuracy of the disclosures made in this Offer to
      Purchase.

      -2-

          3.

            Refer to the question “What is the CVR and how does it work?” In the third bullet point you describe the Additional Closing Net Cash Proceeds. Please revise this disclosure to describe in detail the various
              reductions to the Closing Net Cash specified in the merger agreement.

    Response: In response to the Staff’s comment, the Co-Offerors have revised the third bullet point of the question “What is the CVR and how does it work?” in
      the section entitled “Summary Term Sheet” in the Offer to Purchase, to add the following underlined language and remove the following strikethrough language:

    Any Additional Closing Net Cash Proceeds would be calculated and payable based on the realization of any net savings equal to the amount by which the Closing Net Cash as finally determined pursuant
      to the merger agreement exceeds $475,000,000, adjusted downward for any claims or downward or upward, as applicable, for any changes in amounts accrued in the Closing Net Cash that, in each case: (i) are not accounted for in such Closing Net Cash;
      (ii) Parent reasonably determines to be valid; and (iii) arise prior to the CVR Payment Date (as defined in the CVR Agreement) with respect to any Additional Closing Net Cash Proceeds., which is no later than thirty (30) days following the Merger Closing Date. We cannot predict whether any net savings will be realized at
      all, or to what extent. Net savings would depend upon various unknown factors, including unforeseen claims and costs that iTeos may incur. “Closing Net Cash” as defined in the Merger Agreement and as used herein,
          means, without duplication, (i) iTeos’ cash, cash equivalents and investments as of the Cash Determination Time, determined in accordance with GAAP, applied on a basis consistent with iTeos’ application thereof in iTeos’ consolidated financial
          statements, minus (ii) Indebtedness of iTeos and its subsidiaries as of the Cash Determination Time, minus (iii) the Transaction Expenses, minus (iv) the Estimated Costs Post-Merger Closing, minus (v) $350,000 for the CVR Expense Cap under the CVR Agreement.

          4.

            Refer to the question “What is the CVR and how does it work?” In the fifth bullet point you state that Parent “...shall...use commercially reasonable efforts to spend up to $350,000...” to take various actions.
              It is unclear whether the “commercially reasonable efforts” are to be made with respect to spending the stated funds or to effect the actions listed, in which case the expenses would be subject to the CVR Expense Cap. Please revise.

    Response: In response to the Staff’s comment, the Co-Offerors have revised the fifth bullet point of the question “What is the CVR and how does it work?” in
      the section entitled “Summary Term Sheet” in the Offer to Purchase, to add the following underlined language:

    During the Disposition Period, Parent shall, and shall cause Merger Sub, licensees and rights transferees to use commercially reasonable efforts to spend up to $350,000 (the “CVR Expense Cap”) to:
      (i) enter into one or more agreements providing for a sale, transfer, license or other disposition of all or any part of the CVR Products (each a “Disposition Agreement”) as soon as practicable following the Effective Time; (ii) retain an employee or
      consultant of Parent or Merger Sub for the purpose of maintaining and preserving the CVR Products (as defined in the CVR Agreement) and seeking, negotiating and executing Disposition Agreements; (iii) maintain the CVRs (including fees and expenses
      related to the Rights Agent and the Representative); (iv) maintain and prosecute the intellectual property relating to the CVR Products; and (v) continue the CMC Activities (as defined in the Merger Agreement) of the CVR Products to the extent the
      costs associated with such CMC Activities were included in the Closing Net Cash Schedule. For the avoidance of doubt, Parent and Merger Sub are not obligated to pursue new clinical, manufacturing or enabling work with respect to the CVR Products. The Co-Offerors will be obligated to use commercially reasonable efforts to effect the actions set forth in (i)-(iv) listed above, but in no event will be obligated to spend more than the CVR Expense Cap to effect such
          actions. The Co-Offerors will be obligated use commercially reasonable efforts to effect the actions set forth in (v) listed above, but in no event will be obligated to spend more than the costs associated with such CMC Activities in the Closing
          Net Cash Schedule to effect such actions.

      -3-

          5.

            On a related note, and only to the extent any revised disclosure in response to the prior comment does not address it, please describe what efforts the bidders are required to make in order to bring about the
              developments that may result in a CVR payment to security holders.

    Response: The Co-Offerors acknowledge the Staff’s comment and respectfully refer the Staff to Co-Offeror’s response to Question #4 above.

          6.

            Refer to the question “If I accept the offer, when and how will I get paid?” Please tell us why the bidders will need up to thirty days to make payments pursuant to the CVR. We note that, in the case of a payment
              arising out of any Additional Closing Net Cash, it would appear that a merger would be completed shortly after the expiration of the offer.

    Response: In response to the Staff’s comment, the Co-Offerors respectfully submit that the Additional Closing Net Cash Proceeds are paid no later than thirty
      (30) days following the Merger Closing Date to ensure that any adjustments upward or downward to Closing Net Cash, as finally determined pursuant to Section 2.01(c) of the Merger Agreement, are appropriately accounted for in the calculation of
      Additional Closing Net Cash Proceeds pursuant to the CVR Agreement. During the thirty (30) days following the Merger Closing Date, the Co-Offerors will continue to receive and reconcile any refunds, invoices, credit card statements, payroll data,
      wind-down expenses and other similar items and amounts, which are included in the calculation of Adjusted Closing Net Cash Proceeds.

    * * * * *

      -4-

    If you have any further questions or comments, or if you require any additional information, please contact Ryan Murr of Gibson, Dunn & Crutcher LLP, by telephone at (415) 393-8373. Thank you for
      your assistance.

            Very truly yours,

          By:

            /s/ Ryan Murr

            Ryan Murr

    Via e-mail:

            cc:

            James Moloney, Gibson, Dunn & Crutcher LLP

            Kevin Tang, Concentra Biosciences, LLC

            Michael Hearne, Concentra Biosciences, LLC