SecProbe.io

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Zhengye Biotechnology Holding Limited

September 26, 2024

Via EDGAR

Division of Corporation Finance

Office of Life Sciences

U.S. Securities and Exchange Commission

100 F Street, NE

Washington, D.C., 20549

    Attention:
    Franklin Wyman

    Daniel Gordon

    Doris Stacey Gama

    Jason Drory

    Re:
    Zhengye Biotechnology Holding Limited

    Registration Statement on Form F-1, as amended

    Initially Filed on January 9, 2024

    File No. 333-276436

Ladies and Gentlemen:

In accordance with Rule 461
of the General Rules and Regulations under the Securities Act of 1933, as amended, Zhengye Biotechnology Holding Limited hereby requests
that the effectiveness of the above-referenced Registration Statement on Form F-1, as amended, be accelerated to and that the Registration
Statement become effective at 4:30 p.m., Eastern Time, on September 30, 2024, or as soon thereafter as practicable.

    Very truly yours,

    Zhengye Biotechnology Holding Limited

    By:
    /s/ Songlin Song

    Name:
     Songlin Song

    Title:
    Chief Executive Director