Correspondence 0001193125-24-149345 from Rapport Therapeutics, Inc. (RAPP)
Rapport Therapeutics, Inc.
Date: May 29, 2024 · CIK: 0002012593 · Accession: 0001193125-24-149345
AI Filing Summary & Sentiment
Reasoning
File numbers found in text: 333-279486
Referenced dates: April 24, 2024
Letter
VIA EDGAR, FACSIMILE AND FEDERAL EXPRESS Division of Corporation Finance Office of Life Sciences Attention: Tamika Sheppard, Joe McCann, Daniel Gordon and Jenn Do Registration Statement on Form S-1 File No. 333-279486 CIK No. 0002012593 Rule 83 Confidential Treatment Request by Rapport Therapeutics, Inc.
Dear Ladies and Gentlemen:
On behalf of Rapport Therapeutics, Inc. (the “Company”), in response to comments from the staff (the “Staff”) of the Securities and Exchange Commission (the “Commission”) received by letter dated April 24, 2024 (the “Comment Letter”) relating to the Company’s Registration Statement on Form S-1, originally confidentially submitted to the Commission on March 27, 2024, and subsequently publicly filed by the Company with the Commission on May 17, 2024 (File No. 333-279486) (the “Registration Statement”), we submit this supplemental letter to address comment 5 of the Comment Letter.
Division of Corporation Finance
Office of Life Sciences
U.S. Securities and Exchange Commission
May 29, 2024
Page
Because of the commercially sensitive nature of information contained herein, this submission is accompanied by the Company’s request for confidential treatment for selected portions of this letter. The Company has concurrently filed a separate letter with the Office of Freedom of Information and Privacy Act Operations in connection with the confidential treatment request, pursuant to Rule 83 of the Commission’s Rules on Information and Requests, 17 C.F.R. § 200.83. For the Staff’s reference, we have enclosed a copy of the Company’s letter to the Office of Freedom of Information and Privacy Act Operations.
We confirm on behalf of the Company that, prior to circulating copies of the preliminary prospectus in connection with the offering, the Company will file a pre-effective amendment to the Registration Statement that will include all information other than information that may be excluded in reliance upon Rule 430A of Regulation C, and the final price range to be included in such amendment which will comply with the Staff’s interpretation regarding the parameters of a bona fide price range.
Prior to the effectiveness of the Registration Statement, the Company intends to implement a reverse stock split of its common stock (the “Stock Split”). The Company expects to reflect the Stock Split in a pre-effective amendment to the Registration Statement that includes the actual price range. For purposes of this letter, we have presented all dollar and per share amounts without giving effect to the Stock Split to be consistent with the current presentation in the Registration Statement.
The Company respectfully requests that the bracketed information contained in this letter be treated as confidential information pursuant to Rule 83 promulgated by the Commission, 17 C.F.R. §200.8, and that the Commission provide timely notice to Abraham N. Ceesay and Troy I. Ignelzi before it permits any disclosure of the bracketed information in this letter.
For the convenience of the Staff, we have recited the prior comment from the Staff in the Comment Letter in italicized type and have followed the comment with the Company’s response.
5. We note the determination of fair value information provided on page 108. Noting from page F-38 the option grants made in January-March 2024, once you have an estimated offering price or range, please explain to us how you determined the fair value of the common stock underlying your equity issuances and the reasons for any differences between the recent valuations of your common stock leading up to the initial public offering and the estimated offering price.
The Company respectfully submits the below additional information to assist the Staff in its review of the Company’s position with respect to its determination of the fair value of the Company’s common stock, par value $0.001 per share (“Common Stock”), underlying its outstanding equity awards and the reasons for the differences between the recent valuation of its Common Stock and the estimated offering price for its initial public offering (“IPO”).
FOIA CONFIDENTIAL TREATMENT REQUESTED BY RAPPORT THERAPEUTICS, INC.
Division of Corporation Finance
Office of Life Sciences
U.S. Securities and Exchange Commission
May 29, 2024
Page
Determining the Fair Value of Common Stock Prior to the IPO
As there has been no public market for the Common Stock to date, the estimated fair value of its Common Stock has been determined by the Company’s board of directors (the “Board”) as of the date of each equity award, with input from management, considering the Company’s most recently available third-party valuations of its Common Stock, and the Board’s assessment of additional objective and subjective factors that it believed were relevant and which may have changed from the date of the most recent valuation through the date of the grant. Subsequent to the Board-approved third-party valuations, the fair values of the Common Stock as of the date of certain equity awards were adjusted in connection with a retrospective fair value assessment for accounting purposes, as described below. These retrospective third-party valuations were performed in accordance with the guidance outlined in the American Institute of Certified Public Accountants’ Accounting and Valuation Guide, Valuation of Privately-Held-Company Equity Securities Issued as Compensation (the “Practice Aid”).
Valuation Methodologies
As disclosed in the Registration Statement, the Company’s enterprise value valuations were prepared using either an option pricing method (“OPM”) market-adjusted back-solve approach based on a recent arms-length transaction, or the probability-weighted expected return method (“PWERM”), with an IPO scenario and either a sale scenario or a continued operation scenario. The Company’s enterprise value in the IPO scenario was based on guideline IPO transactions identified within the last one to three years, which was adjusted by a risk-adjusted discount rate. The Company’s enterprise value for the continued operation scenario was based on an OPM market-adjusted back-solve method. The estimated enterprise value was then allocated to Common Stock using a current value method (“CVM”) for the IPO scenario. Under the CVM, the common stock has value only if the funds available for distribution to stockholders exceeded the value of the convertible preferred stock liquidation preferences at the time of the liquidity event. A discount for lack of marketability (“DLOM”) of the common stock is then applied to arrive at an indication of value for the common stock. The OPM and a calibration analysis were used for the continued operation scenario. The OPM treats common stock and convertible preferred stock as call options on the total equity value of a company, with exercise prices based on the value thresholds at which the allocation among the various holders of a company’s securities changes. The calibration analysis is an approach that considers the changes in the market and the company’s operations since the latest round of equity financing and adjusts the previously derived equity value for those changes.
FOIA CONFIDENTIAL TREATMENT REQUESTED BY RAPPORT THERAPEUTICS, INC.
Division of Corporation Finance
Office of Life Sciences
U.S. Securities and Exchange Commission
May 29, 2024
Page
Board-Approved Third-Party Valuations
The Company’s most recent third-party valuations of its Common Stock utilized by the Board in determining exercise prices at the time of each equity award were as follows:
Date of Third-Party Valuation
Date of Board Approval
Estimated Fair Market Value of Common Stock per Share
August 31, 2023
December 6, 2023
$ 0.21
December 31, 2023
February 7, 2024
$ 0.52
February 26, 2024
March 25, 2024
$ 1.12
March 31, 2024
May 7, 2024
$ 1.35
Equity Awards Between December 6, 2023 and May 7, 2024
The following table summarizes by grant date the number of shares subject to awards granted between December 6, 2023 and May 7, 2024, the per share exercise price of the awards and the fair value of Common Stock underlying the awards on each grant date:
Grant Date
Type of Award
Number of Shares Subject to Award
Per Share Exercise Price or Purchase Price of Award
Per Share Fair Value of Common Stock on Grant Date
Per Share Estimated Fair Value of Award on Grant Date(1)
12/06/2023
Option
11,595,429
$ 0.21
$ 0.74 (2)
$ 0.67
12/06/2023
Option
195,000
$ 0.21
$ 0.74 (3)
$ 0.71 (4)
01/13/2024
Option
300,000
$ 0.21
$ 0.74 (5)
$ 0.67
02/07/2024
Option
1,130,000
$ 0.52
$ 1.12 (6)
$ 0.95
03/25/2024
Option
9,677,077
$ 1.12
$ 1.35 (7)
$ 1.06
03/25/2024
Option
35,000
$ 1.12
$ 1.35 (8)
$ 1.22 (4)
05/07/2024
Option
790,000
$ 1.35
$ 1.35
$ 1.06
(1) The per share estimated fair value of options reflects the fair value of options granted on each grant date determined using the Black-Scholes option-pricing model.
(2) At the time of the option grant to employees on December 6, 2023, the Board determined that the fair value of the Common Stock of $0.21 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes.
(3) At the time of the option grant to consultants on December 6, 2023, the Board determined that the fair value of the Common Stock of $0.21 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes.
FOIA CONFIDENTIAL TREATMENT REQUESTED BY RAPPORT THERAPEUTICS, INC.
Division of Corporation Finance
Office of Life Sciences
U.S. Securities and Exchange Commission
May 29, 2024
Page
(4) The Black-Scholes estimated fair value resulted in a different fair value for these grants as compared to the grants on the same date above because these grants were made to consultants, which requires the use of different assumptions.
(5) At the time of the option grant to a member of the Board on January 13, 2024, the Board determined that the fair value of the Common Stock of $0.21 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes.
(6) At the time of the option grant to employees on February 7, 2024, the Board determined that the fair value of the Common Stock of $0.52 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes.
(7) At the time of the option grant to employees on March 25, 2024, the Board determined that the fair value of the Common Stock of $1.12 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes.
(8) At the time of the option grant to consultants on March 25, 2024, the Board determined that the fair value of the Common Stock of $1.12 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes.
December 6, 2023 and January 13, 2024 Equity Awards
The fair value of the Common Stock of $0.21 per share at August 31, 2023 was determined with the assistance of an independent third-party valuation firm and approved by the Board on December 6, 2023. This valuation was used to support the fair market value of the Common Stock in accordance with Section 409A of the Internal Revenue Service’s Internal Revenue Code (the “IRC”) with respect to options granted on December 6, 2023 and January 13, 2024, along with other factors determined by the Board to be relevant at the time of each such grant of options. This valuation utilized the hybrid method, which included considerations of immediate liquidation scenario and continued operations scenario. The valuation assigned a [***]% probability weight to the immediate liquidation scenario and a [***]% probability weigh to the continued operations scenario. A [***]% DLOM of the Common Stock was then applied to arrive at an indication of value for the Common Stock.
The fair value of the Common Stock as of December 6, 2023 and January 13, 2024 was subsequently adjusted to $0.74 per share, in connection with a retrospective fair value valuation for financial reporting purposes prepared as of December 31, 2023. In particular, the retrospective valuation determined the Company’s enterprise value using the hybrid method, which included a PWERM, with an IPO scenario and a sale scenario. The Company’s enterprise value in the IPO scenario was based on guideline IPO transactions identified within the last one to three years, which was adjusted by a risk-adjusted discount rate. The IPO scenario also assumed an estimated
FOIA CONFIDENTIAL TREATMENT REQUESTED BY RAPPORT THERAPEUTICS, INC.
Division of Corporation Finance
Office of Life Sciences
U.S. Securities and Exchange Commission
May 29, 2024
Page
timeline for the IPO to occur. The valuation assigned a [***]% probability to the IPO scenario. The Company’s enterprise value for the sale scenario was based on an OPM market-adjusted back-solve method based on the $1.67727 price per share paid by new and existing investors in the closing of the Company’s Series B convertible preferred stock in August 2023. The market adjustment applied to the equity value considered the performance of guideline public companies and the biotech indices since the most recent sale of the Company’s convertible preferred stock through the valuation date. The valuation assigned a [***]% probability to the sale scenario. A [***]% and [***]% DLOM of the Common Stock was then applied to the IPO scenario and sale scenario, respectively, to arrive at an indication of value for the Common Stock.
February 7, 2024 Equity Awards
The fair value of the Common Stock of $0.52 per share at December 31, 2023 was determined with the assistance of an independent third-party valuation firm and approved by the Board on February 7, 2024. This valuation was used to support the fair market value of the Common Stock in accordance with Section 409A of the IRC with respect to options granted on February 7, 2024, along with other factors determined by the Board to be relevant at the time of each such grant of options. This valuation utilized the hybrid method, which included considerations of an IPO exit, immedia
Show Raw Text
CORRESP 1 filename1.htm CORRESP Goodwin Procter LLP 100 Northern Avenue Boston, MA 02210 goodwinlaw.com +1 617 570 1000 May 29, 2024 FOIA CONFIDENTIAL TREATMENT REQUESTED The entity requesting confidential treatment is Rapport Therapeutics, Inc. 1325 Boylston Street, Suite 401 Boston, MA 02215 Telephone: (857) 321-8020 CERTAIN PORTIONS OF THIS LETTER HAVE BEEN OMITTED FROM THE VERSION FILED VIA EDGAR. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED PORTIONS. INFORMATION THAT WAS OMITTED IN THE EDGAR VERSION HAS BEEN NOTED IN THIS LETTER WITH A PLACEHOLDER IDENTIFIED BY THE MARK “[***].” VIA EDGAR, FACSIMILE AND FEDERAL EXPRESS U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Tamika Sheppard, Joe McCann, Daniel Gordon and Jenn Do RE: Rapport Therapeutics, Inc. Registration Statement on Form S-1 File No. 333-279486 CIK No. 0002012593 Rule 83 Confidential Treatment Request by Rapport Therapeutics, Inc. Dear Ladies and Gentlemen: On behalf of Rapport Therapeutics, Inc. (the “Company”), in response to comments from the staff (the “Staff”) of the Securities and Exchange Commission (the “Commission”) received by letter dated April 24, 2024 (the “Comment Letter”) relating to the Company’s Registration Statement on Form S-1, originally confidentially submitted to the Commission on March 27, 2024, and subsequently publicly filed by the Company with the Commission on May 17, 2024 (File No. 333-279486) (the “Registration Statement”), we submit this supplemental letter to address comment 5 of the Comment Letter. Division of Corporation Finance Office of Life Sciences U.S. Securities and Exchange Commission May 29, 2024 Page 2 Because of the commercially sensitive nature of information contained herein, this submission is accompanied by the Company’s request for confidential treatment for selected portions of this letter. The Company has concurrently filed a separate letter with the Office of Freedom of Information and Privacy Act Operations in connection with the confidential treatment request, pursuant to Rule 83 of the Commission’s Rules on Information and Requests, 17 C.F.R. § 200.83. For the Staff’s reference, we have enclosed a copy of the Company’s letter to the Office of Freedom of Information and Privacy Act Operations. We confirm on behalf of the Company that, prior to circulating copies of the preliminary prospectus in connection with the offering, the Company will file a pre-effective amendment to the Registration Statement that will include all information other than information that may be excluded in reliance upon Rule 430A of Regulation C, and the final price range to be included in such amendment which will comply with the Staff’s interpretation regarding the parameters of a bona fide price range. Prior to the effectiveness of the Registration Statement, the Company intends to implement a reverse stock split of its common stock (the “Stock Split”). The Company expects to reflect the Stock Split in a pre-effective amendment to the Registration Statement that includes the actual price range. For purposes of this letter, we have presented all dollar and per share amounts without giving effect to the Stock Split to be consistent with the current presentation in the Registration Statement. The Company respectfully requests that the bracketed information contained in this letter be treated as confidential information pursuant to Rule 83 promulgated by the Commission, 17 C.F.R. §200.8, and that the Commission provide timely notice to Abraham N. Ceesay and Troy I. Ignelzi before it permits any disclosure of the bracketed information in this letter. For the convenience of the Staff, we have recited the prior comment from the Staff in the Comment Letter in italicized type and have followed the comment with the Company’s response. 5. We note the determination of fair value information provided on page 108. Noting from page F-38 the option grants made in January-March 2024, once you have an estimated offering price or range, please explain to us how you determined the fair value of the common stock underlying your equity issuances and the reasons for any differences between the recent valuations of your common stock leading up to the initial public offering and the estimated offering price. The Company respectfully submits the below additional information to assist the Staff in its review of the Company’s position with respect to its determination of the fair value of the Company’s common stock, par value $0.001 per share (“Common Stock”), underlying its outstanding equity awards and the reasons for the differences between the recent valuation of its Common Stock and the estimated offering price for its initial public offering (“IPO”). 2 FOIA CONFIDENTIAL TREATMENT REQUESTED BY RAPPORT THERAPEUTICS, INC. Division of Corporation Finance Office of Life Sciences U.S. Securities and Exchange Commission May 29, 2024 Page 3 Determining the Fair Value of Common Stock Prior to the IPO As there has been no public market for the Common Stock to date, the estimated fair value of its Common Stock has been determined by the Company’s board of directors (the “Board”) as of the date of each equity award, with input from management, considering the Company’s most recently available third-party valuations of its Common Stock, and the Board’s assessment of additional objective and subjective factors that it believed were relevant and which may have changed from the date of the most recent valuation through the date of the grant. Subsequent to the Board-approved third-party valuations, the fair values of the Common Stock as of the date of certain equity awards were adjusted in connection with a retrospective fair value assessment for accounting purposes, as described below. These retrospective third-party valuations were performed in accordance with the guidance outlined in the American Institute of Certified Public Accountants’ Accounting and Valuation Guide, Valuation of Privately-Held-Company Equity Securities Issued as Compensation (the “Practice Aid”). Valuation Methodologies As disclosed in the Registration Statement, the Company’s enterprise value valuations were prepared using either an option pricing method (“OPM”) market-adjusted back-solve approach based on a recent arms-length transaction, or the probability-weighted expected return method (“PWERM”), with an IPO scenario and either a sale scenario or a continued operation scenario. The Company’s enterprise value in the IPO scenario was based on guideline IPO transactions identified within the last one to three years, which was adjusted by a risk-adjusted discount rate. The Company’s enterprise value for the continued operation scenario was based on an OPM market-adjusted back-solve method. The estimated enterprise value was then allocated to Common Stock using a current value method (“CVM”) for the IPO scenario. Under the CVM, the common stock has value only if the funds available for distribution to stockholders exceeded the value of the convertible preferred stock liquidation preferences at the time of the liquidity event. A discount for lack of marketability (“DLOM”) of the common stock is then applied to arrive at an indication of value for the common stock. The OPM and a calibration analysis were used for the continued operation scenario. The OPM treats common stock and convertible preferred stock as call options on the total equity value of a company, with exercise prices based on the value thresholds at which the allocation among the various holders of a company’s securities changes. The calibration analysis is an approach that considers the changes in the market and the company’s operations since the latest round of equity financing and adjusts the previously derived equity value for those changes. 3 FOIA CONFIDENTIAL TREATMENT REQUESTED BY RAPPORT THERAPEUTICS, INC. Division of Corporation Finance Office of Life Sciences U.S. Securities and Exchange Commission May 29, 2024 Page 4 Board-Approved Third-Party Valuations The Company’s most recent third-party valuations of its Common Stock utilized by the Board in determining exercise prices at the time of each equity award were as follows: Date of Third-Party Valuation Date of Board Approval Estimated Fair Market Value of Common Stock per Share August 31, 2023 December 6, 2023 $ 0.21 December 31, 2023 February 7, 2024 $ 0.52 February 26, 2024 March 25, 2024 $ 1.12 March 31, 2024 May 7, 2024 $ 1.35 Equity Awards Between December 6, 2023 and May 7, 2024 The following table summarizes by grant date the number of shares subject to awards granted between December 6, 2023 and May 7, 2024, the per share exercise price of the awards and the fair value of Common Stock underlying the awards on each grant date: Grant Date Type of Award Number of Shares Subject to Award Per Share Exercise Price or Purchase Price of Award Per Share Fair Value of Common Stock on Grant Date Per Share Estimated Fair Value of Award on Grant Date(1) 12/06/2023 Option 11,595,429 $ 0.21 $ 0.74 (2) $ 0.67 12/06/2023 Option 195,000 $ 0.21 $ 0.74 (3) $ 0.71 (4) 01/13/2024 Option 300,000 $ 0.21 $ 0.74 (5) $ 0.67 02/07/2024 Option 1,130,000 $ 0.52 $ 1.12 (6) $ 0.95 03/25/2024 Option 9,677,077 $ 1.12 $ 1.35 (7) $ 1.06 03/25/2024 Option 35,000 $ 1.12 $ 1.35 (8) $ 1.22 (4) 05/07/2024 Option 790,000 $ 1.35 $ 1.35 $ 1.06 (1) The per share estimated fair value of options reflects the fair value of options granted on each grant date determined using the Black-Scholes option-pricing model. (2) At the time of the option grant to employees on December 6, 2023, the Board determined that the fair value of the Common Stock of $0.21 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes. (3) At the time of the option grant to consultants on December 6, 2023, the Board determined that the fair value of the Common Stock of $0.21 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes. 4 FOIA CONFIDENTIAL TREATMENT REQUESTED BY RAPPORT THERAPEUTICS, INC. Division of Corporation Finance Office of Life Sciences U.S. Securities and Exchange Commission May 29, 2024 Page 5 (4) The Black-Scholes estimated fair value resulted in a different fair value for these grants as compared to the grants on the same date above because these grants were made to consultants, which requires the use of different assumptions. (5) At the time of the option grant to a member of the Board on January 13, 2024, the Board determined that the fair value of the Common Stock of $0.21 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes. (6) At the time of the option grant to employees on February 7, 2024, the Board determined that the fair value of the Common Stock of $0.52 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes. (7) At the time of the option grant to employees on March 25, 2024, the Board determined that the fair value of the Common Stock of $1.12 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes. (8) At the time of the option grant to consultants on March 25, 2024, the Board determined that the fair value of the Common Stock of $1.12 per share reasonably reflected the fair value of the Common Stock as of the grant date. However, the fair value of the Common Stock as of the date as of the date of this grant was adjusted in connection with a retrospective fair value assessment for accounting purposes. December 6, 2023 and January 13, 2024 Equity Awards The fair value of the Common Stock of $0.21 per share at August 31, 2023 was determined with the assistance of an independent third-party valuation firm and approved by the Board on December 6, 2023. This valuation was used to support the fair market value of the Common Stock in accordance with Section 409A of the Internal Revenue Service’s Internal Revenue Code (the “IRC”) with respect to options granted on December 6, 2023 and January 13, 2024, along with other factors determined by the Board to be relevant at the time of each such grant of options. This valuation utilized the hybrid method, which included considerations of immediate liquidation scenario and continued operations scenario. The valuation assigned a [***]% probability weight to the immediate liquidation scenario and a [***]% probability weigh to the continued operations scenario. A [***]% DLOM of the Common Stock was then applied to arrive at an indication of value for the Common Stock. The fair value of the Common Stock as of December 6, 2023 and January 13, 2024 was subsequently adjusted to $0.74 per share, in connection with a retrospective fair value valuation for financial reporting purposes prepared as of December 31, 2023. In particular, the retrospective valuation determined the Company’s enterprise value using the hybrid method, which included a PWERM, with an IPO scenario and a sale scenario. The Company’s enterprise value in the IPO scenario was based on guideline IPO transactions identified within the last one to three years, which was adjusted by a risk-adjusted discount rate. The IPO scenario also assumed an estimated 5 FOIA CONFIDENTIAL TREATMENT REQUESTED BY RAPPORT THERAPEUTICS, INC. Division of Corporation Finance Office of Life Sciences U.S. Securities and Exchange Commission May 29, 2024 Page 6 timeline for the IPO to occur. The valuation assigned a [***]% probability to the IPO scenario. The Company’s enterprise value for the sale scenario was based on an OPM market-adjusted back-solve method based on the $1.67727 price per share paid by new and existing investors in the closing of the Company’s Series B convertible preferred stock in August 2023. The market adjustment applied to the equity value considered the performance of guideline public companies and the biotech indices since the most recent sale of the Company’s convertible preferred stock through the valuation date. The valuation assigned a [***]% probability to the sale scenario. A [***]% and [***]% DLOM of the Common Stock was then applied to the IPO scenario and sale scenario, respectively, to arrive at an indication of value for the Common Stock. February 7, 2024 Equity Awards The fair value of the Common Stock of $0.52 per share at December 31, 2023 was determined with the assistance of an independent third-party valuation firm and approved by the Board on February 7, 2024. This valuation was used to support the fair market value of the Common Stock in accordance with Section 409A of the IRC with respect to options granted on February 7, 2024, along with other factors determined by the Board to be relevant at the time of each such grant of options. This valuation utilized the hybrid method, which included considerations of an IPO exit, immedia