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May 15, 2024
Adam Stone
Chief Executive Officer
Perceptive Capital Solutions Corp
51 Astor Place, 10th Floor
New York, New York 10003
Re:Perceptive Capital Solutions Corp
Draft Registration Statement on Form S-1
Submitted April 16, 2024
CIK No. 0002017526
Dear Adam Stone:
            We have reviewed your draft registration statement and have the following comments.
            Please respond to this letter by providing the requested information and either submitting
an amended draft registration statement or publicly filing your registration statement on
EDGAR. If you do not believe a comment applies to your facts and circumstances or do not
believe an amendment is appropriate, please tell us why in your response.
            After reviewing the information you provide in response to this letter and your amended
draft registration statement or filed registration statement, we may have additional comments.
Draft Registration Statement on Form S-1 submitted April 16, 2024
Experience with Special Purpose Acquisition Vehicles, page 4
1.On pages 4-5 where you discuss the prior SPAC/de-SPAC experience of your
management team, and elsewhere as appropriate, please disclose the current trading price
of each post-combination publicly listed entity's common stock.
Risk Factors
Risks Relating to our Search for, Consummation of, or Inability to Consummate, a Business
Combination
If we are deemed to be an investment company under the Investment Company Act ..., page 53
2.Please expand your disclosure to include the risk to investors of the loss of the
investment opportunity in a target company. Additionally, please confirm that if your facts
and circumstances change over time, you will update your disclosure to reflect how those
changes impact the risk that you may be considered to be operating as an unregistered

 FirstName LastNameAdam Stone
 Comapany NamePerceptive Capital Solutions Corp
 May 15, 2024 Page 2
 FirstName LastName
Adam Stone
Perceptive Capital Solutions Corp
May 15, 2024
Page 2
investment company.
Effecting Our Initial Business Combination
Employees, page 115
3.We refer to your disclosure on page 26 regarding payments to your sponsor for the
allocable costs of employees of an affiliate of your sponsor or otherwise. Please revise
here or elsewhere as applicable to describe the material terms of any such arrangements.
Principal Shareholders, page 127
4.Please revise to identify Perceptive Advisors as a promoter or advise us as appropriate.
Description of Securities
Contractual transfer restrictions, page 147
5.Please reconcile your disclosures here and elsewhere regarding the duration of the transfer
restrictions applicable to the founder shares. More specifically, we note several references
to "the restriction not to transfer the founder shares for 180 days following the date of this
prospectus," which is inconsistent with the transfer restriction lasting, in part, until one
year after the completion of your initial business combination.
            Please contact Jeffrey Lewis at 202-551-6216 or Jennifer Monick at 202-551-3295 if you
have questions regarding comments on the financial statements and related matters. Please
contact Benjamin Holt at 202-551-6614 or David Link at 202-551-3356 with any other
questions.
Sincerely,
Division of Corporation Finance
Office of Real Estate & Construction
cc:       Peter Seligson