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Correspondence 0001193125-24-234371 from Upstream Bio, Inc. (UPB) (CIK 0002022626) (UPB)

Upstream Bio, Inc. (UPB) (CIK 0002022626)
Date: Oct. 8, 2024 · CIK: 0002022626 · Accession: 0001193125-24-234371

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File numbers found in text: 333-282197

Date
October 8, 2024
Author
E. Rand Sutherland
Form
CORRESP
Company
Upstream Bio, Inc. (UPB) (CIK 0002022626)

Letter

VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences Attention: Chris Edwards, Jimmy McNamara, Kevin Kuhar and Franklin Wyman Re: Upstream Bio, Inc. Acceleration Request for Registration Statement on Form S-1 File No. 333-282197

Dear Ladies and Gentlemen,

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), Upstream Bio, Inc. (the “Company”) hereby requests that the effective date of the above-referenced registration statement (the “Registration Statement”) be accelerated to October 10, 2024 at 4:01 p.m. Eastern Time, or as soon thereafter as practicable, unless we or our outside counsel, Goodwin Procter LLP, request by telephone that such Registration Statement be declared effective at some other time. In making this acceleration request, the Company acknowledges that it is aware of its responsibilities under the Act.

Once the Registration Statement is effective, please orally confirm the event with our counsel, Goodwin Procter LLP, by calling Gabriela Morales-Rivera at (617) 570-1329.

If you have any questions regarding this request, please contact Gabriela Morales-Rivera of Goodwin Procter LLP at (617) 570-1329.

Sincerely,
UPSTREAM BIO, INC.

Show Raw Text
CORRESP
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filename1.htm

CORRESP

 VIA EDGAR

October 8, 2024

 United States Securities and Exchange
Commission

 Division of Corporation Finance

 Office of Life
Sciences

 100 F. Street, N.E.

 Washington, D.C. 20549

Attention: Chris Edwards, Jimmy McNamara, Kevin Kuhar and Franklin Wyman

Re:

Upstream Bio, Inc.

Acceleration Request for Registration Statement on Form S-1

File No. 333-282197

 Dear Ladies and Gentlemen,

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), Upstream Bio, Inc. (the
“Company”) hereby requests that the effective date of the above-referenced registration statement (the “Registration Statement”) be accelerated to October 10, 2024 at 4:01 p.m. Eastern Time, or as soon
thereafter as practicable, unless we or our outside counsel, Goodwin Procter LLP, request by telephone that such Registration Statement be declared effective at some other time. In making this acceleration request, the Company acknowledges that it
is aware of its responsibilities under the Act.

 Once the Registration Statement is effective, please orally confirm the event with our
counsel, Goodwin Procter LLP, by calling Gabriela Morales-Rivera at (617) 570-1329.

 If you have
any questions regarding this request, please contact Gabriela Morales-Rivera of Goodwin Procter LLP at (617) 570-1329.

Sincerely,

 UPSTREAM BIO, INC.

 /s/ E. Rand Sutherland

E. Rand Sutherland

 Chief
Executive Officer

cc:
 E. Rand Sutherland, M.D., M.P.H., Upstream Bio, Inc.

Michael Paul Gray, M.B.A., Upstream Bio, Inc.

Gabriela Morales-Rivera, Esq., Goodwin Procter LLP

William D. Collins, Esq., Goodwin Procter LLP

Kathryn W. Clerici, Esq., Goodwin Procter LLP