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VIA EDGAR

January 14, 2022

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attn: Kristin Lochhead and Brian Cascio

    Re:
    BioCryst Pharmaceuticals, Inc.

    Form 10-K for the Fiscal Year Ended December 31, 2020

    Filed March 1, 2021

    File No. 000-23186

Dear Ladies and Gentlemen:

On behalf of BioCryst Pharmaceuticals,
Inc. (the “Company”), set forth below is the Company’s response to the comment letter dated December 14, 2021
from the staff (the “Staff”) of the Securities and Exchange Commission in connection with the Staff’s review
of the Company’s annual report on Form 10-K for the fiscal year ended December 31, 2020. For ease of reference, the numbered paragraph
below corresponds to the numbered comment in your letter, with your comment presented in bold followed by the related response.

Notes to Consolidated Financial Statements

Note 3. Royalty Monetizations, page 64

 1. We see that you used level 3 inputs to determine the fair value of the ORLADEYO royalty financing obligation.
Please tell us where you provided all of the relevant disclosures required by ASC 820-10-50, including quantitative information about
the significant unobservable inputs used in the fair value measurement.

The Company acknowledges
the Staff’s comment and respectfully informs the Staff that the ORLADEYO® royalty financing obligation was recorded
at fair value as of the transaction date but is then recorded at its carrying value in subsequent periods. As the disclosure requirements
in ASC 820 are focused solely on fair value measurements recorded subsequent to the initial recognition, we determined the relevant disclosures
of ASC 820-10-50 are not applicable.

As disclosed in
Note 3, the Company recorded the ORLADEYO financing obligation at fair value at the time of the transaction (December 7, 2020) based on
estimated future royalties due, which were based on level 3 unobservable inputs. However, the financing obligation is subsequently recorded
at its carrying value in accordance with ASC 470 based on the application of the effective interest method. ASC 470 requires amounts recorded
as debt to be amortized under the interest method, and accordingly, the Company determines the effective interest rate based on future
royalty payments to be made to the counterparty. In applying the effective interest method, if there is a change in estimated cash flows
from future revenue, the Company utilizes the prospective method to periodically assess and adjust the carrying value based on estimated
future cash payments. At December 31, 2020, there were no changes to the estimated future cash royalty payments used in the initial estimate
to record the fair value as of the transaction date of December 7, 2020.

For clarity, the
Company will revise future filings to include the following enhanced disclosure relative to the ongoing accounting treatment:

The fair value
for the royalty financing obligation at the time of the transaction was based on the Company’s estimates of future royalties expected
to be paid to the counterparty over the life of the arrangement. The Company subsequently records the obligation at its carrying value
using the effective interest method. In order to amortize the royalty financing obligation, the Company utilizes the prospective method
to estimate the future royalties to be paid by the Company to the counterparty over the life of the arrangement. Under the prospective
method, a new effective interest rate is determined based on the revised estimate of remaining cash flows. The new rate is the discount
rate that equates the present value of the revised estimate of remaining cash flows with the carrying amount of the debt, and it will
be used to recognize interest expense for the remaining periods. The Company periodically assesses the amount and timing of expected royalty
payments using a combination of internal projections and forecasts from external sources. To the extent such payments are greater or less
than our initial estimates or the timing of such payments is materially different than its original estimates, the Company will prospectively
adjust the amortization of the royalty financing obligation and the effective interest rate.

If you have any additional
questions or comments or require further information with respect to the foregoing, please call the undersigned at (919) 859-7930 or Brian
Lane of Gibson, Dunn & Crutcher LLP at (202) 887-3646.

    Very truly yours,

    /s/ Alane Barnes

    Alane Barnes

    Chief Legal Officer

    cc:
    Brian Lane, Gibson, Dunn & Crutcher LLP

    Mark Baxter, Ernst & Young LLP

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