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CORRESP Filing

ONCOLYTICS BIOTECH INC
Date: Dec. 5, 2025 · CIK: 0001129928 · Accession: 0001104659-25-118931

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File numbers found in text: 333-290954

Date
December 5, 2025
Author
Kirk Look
Form
CORRESP
Company
ONCOLYTICS BIOTECH INC

Letter

ONCOLYTICS BIOTECH INC.

Suite 804, 322 11th Avenue SW

Calgary, Alberta, Canada, T2R 0C5

VIA EDGAR

December 5, 2025

United States Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attention: Jimmy McNamara

Re: Oncolytics Biotech Inc.

Registration Statement on Form F-4

File No. 333-290954

To the addressee set forth above:

Pursuant to Rule 461 of the U.S. Securities Act of 1933, as amended, Oncolytics Biotech Inc. (the "Company") hereby requests acceleration of the effective date of its registration statement on Form F-4 (File No. 333-290954) (the "Registration Statement"), to 4:00 p.m. Eastern Time on December 9, 2025, or as soon thereafter as practicable.

Please contact Christopher J. Clark of Latham & Watkins LLP, special U.S. counsel to the Company, at (202) 637-2374 or Christopher.J.Clark@lw.com, as soon as the Registration Statement has been declared effective, or if you have any other questions or concerns regarding this matter.

Very truly yours,
ONCOLYTICS BIOTECH INC.

Show Raw Text
CORRESP
 1
 filename1.htm

 ONCOLYTICS BIOTECH INC.

 Suite 804, 322 11th Avenue SW

 Calgary, Alberta, Canada, T2R 0C5

 VIA EDGAR

 December 5, 2025

 United States Securities and Exchange Commission

 Division of Corporation Finance

 Office of Life Sciences

 100 F Street, N.E.

 Washington, D.C. 20549

 Attention:
 Jimmy McNamara

 Re:
 Oncolytics Biotech Inc.

 Registration Statement on Form F-4

 File No. 333-290954

 To the addressee set forth above:

 Pursuant to Rule 461
of the U.S. Securities Act of 1933, as amended, Oncolytics Biotech Inc. (the "Company") hereby requests acceleration of the
effective date of its registration statement on Form F-4 (File No. 333-290954) (the "Registration Statement"),
to 4:00 p.m. Eastern Time on December 9, 2025, or as soon thereafter as practicable.

 Please contact Christopher
J. Clark of Latham & Watkins LLP, special U.S. counsel to the Company, at (202) 637-2374 or Christopher.J.Clark@lw.com, as soon
as the Registration Statement has been declared effective, or if you have any other questions or concerns regarding this matter.

 Very truly yours,

 ONCOLYTICS BIOTECH INC.

 By:
 /s/ Kirk Look

 Name:
 Kirk Look

 Title:
 Chief Financial Officer

 cc:   Christopher
J. Clark, Esq., Latham & Watkins LLP