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SEC Comment Letter for Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802) (KPTI) — Nov 21, 2016

Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)
Date: Nov. 21, 2016 · CIK: 0001503802 · Accession: 0000000000-16-101786

Offering / Registration Process Regulatory Compliance Financial Reporting

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File numbers found in text: 333-214489

Date
November 18, 2016
Author
/s/ Mary Beth Breslin for
Form
UPLOAD
Company
Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)

Letter

Mail Stop 4546 November 18, 2016 Michael G. Kauffman, M.D., Ph.D. Chief Executive Officer Karyopharm Therapeutics Inc. 85 Wells Avenue, 2nd Floor Newton, MA 02459

Re: Karyopharm Therapeutics Inc. Registration Statement on Form S-3 Filed November 8, 2016 File No. 333-214489

Dear Dr. Kauffman :

This is to advise you that we have not reviewed and will not review your registration statement .

Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff.

Please contact Scot Foley at (202) 551 -3383 or Mary Beth Breslin at (202) 551 -3625 with any questions.

Sincerely,
/s/ Mary Beth Breslin for

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Mail Stop 4546

November 18, 2016

Michael G. Kauffman, M.D., Ph.D.
Chief Executive Officer
Karyopharm Therapeutics  Inc.
85 Wells Avenue, 2nd Floor
Newton, MA 02459

Re: Karyopharm Therapeutics Inc.
  Registration Statement on Form S-3
Filed  November 8, 2016
  File No.  333-214489

Dear Dr. Kauffman :

This is to advise you that we have not  reviewed and will not review your registration
statement .

Please refer to Rules 460 and 461 regarding requests for acceleration.  We remind you
that the company and its management are responsible for the accuracy and adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action by the staff.

Please contact Scot Foley at (202) 551 -3383 or Mary Beth Breslin at (202) 551 -3625  with
any questions.

Sincerely,

 /s/ Mary Beth Breslin for

Suzanne Hayes
Assistant Director
        Office of Healthcare and Insurance

cc:  Steven D. Singer, Esq.