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SEC Company Response from Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802) (KPTI) — May 2, 2016

Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)
Date: May 2, 2016 · CIK: 0001503802 · Accession: 0001193125-16-572593

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File numbers found in text: 333-201366

Date
May 2, 2016
Author
Christopher B. Primiano
Form
CORRESP
Company
Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)

Letter

Karyopharm Therapeutics Inc.

85 Wells Avenue, 2nd Floor

Newton, MA 02459

May 2, 2016

VIA EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Re: Karyopharm Therapeutics Inc.

Post-Effective Amendment No. 2 to Registration Statement on Form S-3

File No. 333-201366

Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Karyopharm Therapeutics Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Post-Effective Amendment No. 2 to Registration Statement on Form S-3 (File No. 333-201366) (the “Registration Statement”), so that it may become effective at 4:00 p.m. Eastern Time on May 4, 2016, or as soon thereafter as practicable.

The Registrant hereby acknowledges that:

(i) should the Securities and Exchange Commission (the “Commission”) or the staff, acting pursuant to delegated authority, declare the Registration Statement effective, it does not foreclose the Commission from taking any action with respect to the Registration Statement;

(ii) the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the Registration Statement effective, does not relieve the Registrant from its full responsibility for the adequacy and accuracy of the disclosure in the Registration Statement; and

(iii) the Registrant may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

Very truly yours,
KARYOPHARM THERAPEUTICS INC.

Show Raw Text
CORRESP
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CORRESP

 Karyopharm Therapeutics Inc.

85 Wells Avenue, 2nd Floor

 Newton,
MA 02459

 May 2, 2016

 VIA EDGAR

Securities and Exchange Commission

 Division of Corporation
Finance

 100 F Street, N.E.

 Washington, D.C. 20549

Re:
Karyopharm Therapeutics Inc.

 Post-Effective Amendment No. 2 to Registration Statement on
Form S-3

 File No. 333-201366

Request for Acceleration

 Ladies and
Gentlemen:

 Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Karyopharm Therapeutics Inc. (the
“Registrant”) hereby requests acceleration of the effective date of its Post-Effective Amendment No. 2 to Registration Statement on Form S-3 (File No. 333-201366) (the “Registration Statement”), so that it may become
effective at 4:00 p.m. Eastern Time on May 4, 2016, or as soon thereafter as practicable.

 The Registrant hereby acknowledges that:

(i)
should the Securities and Exchange Commission (the “Commission”) or the staff, acting pursuant to delegated authority, declare the Registration Statement effective, it does not foreclose the Commission from
taking any action with respect to the Registration Statement;

(ii)
the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the Registration Statement effective, does not relieve the Registrant from its full responsibility for the adequacy and
accuracy of the disclosure in the Registration Statement; and

(iii)
the Registrant may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

Very truly yours,

KARYOPHARM THERAPEUTICS INC.

By:

 /s/ Christopher B. Primiano

Christopher B. Primiano

Senior Vice President, Corporate Development, General Counsel and Secretary