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SEC Company Response from Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802) (KPTI) — Feb 13, 2018

Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)
Date: Feb. 13, 2018 · CIK: 0001503802 · Accession: 0001193125-18-041454

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File numbers found in text: 333-222726

Date
February 13, 2018
Author
Christopher B. Primiano
Form
CORRESP
Company
Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)

Letter

KARYOPHARM THERAPEUTICS INC.

85 WELLS AVENUE, SECOND FLOOR

NEWTON, MA 02459

February 13, 2018

Via EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Re: Karyopharm Therapeutics Inc.

Registration Statement on Form S-3

File No. 333-222726

Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Karyopharm Therapeutics Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-222726), so that it may become effective at 4:00 p.m. Eastern time on February 15, 2018, or as soon thereafter as practicable.

Very truly yours,
Karyopharm Therapeutics Inc.

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CORRESP
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CORRESP

 KARYOPHARM THERAPEUTICS INC.

85 WELLS AVENUE, SECOND FLOOR

NEWTON, MA 02459

February 13, 2018

 Via EDGAR

Securities and Exchange Commission

 Division of Corporation
Finance

 100 F Street, N.E.

 Washington, D.C. 20549

Re:
Karyopharm Therapeutics Inc.

 Registration Statement on Form
S-3

 File No. 333-222726

Request for Acceleration

 Ladies and Gentlemen:

 Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Karyopharm Therapeutics Inc. (the “Registrant”)
hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-222726), so that it may become effective at
4:00 p.m. Eastern time on February 15, 2018, or as soon thereafter as practicable.

Very truly yours,

Karyopharm Therapeutics Inc.

By:

 /s/ Christopher B. Primiano

Name:

Christopher B. Primiano

Title:

Executive Vice President, Chief Business Officer,

General Counsel and Secretary