SEC Company Response from Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802) (KPTI) — Apr 22, 2019
Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)
Date: April 22, 2019 · CIK: 0001503802 · Accession: 0001193125-19-113260
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File numbers found in text: 333-226038
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CORRESP 1 filename1.htm CORRESP KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE, SECOND FLOOR NEWTON, MA 02459 April 22, 2019 Via EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Karyopharm Therapeutics Inc. Post-Effective Amendment No. 2 to Form S-3 Registration Statement File No. 333-226038 Request for Acceleration Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Karyopharm Therapeutics Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Post-Effective Amendment No. 2 to Form S-3 Registration Statement (File No. 333-226038), so that it may become effective at 4:00 p.m. Eastern time on April 24, 2019, or as soon thereafter as practicable. Very truly yours, Karyopharm Therapeutics Inc. By: /s/ Christopher B. Primiano Name: Title: Christopher B. Primiano Executive Vice President, Chief Business Officer, General Counsel and Secretary