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SEC Company Response from Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802) (KPTI) — Apr 22, 2019

Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)
Date: April 22, 2019 · CIK: 0001503802 · Accession: 0001193125-19-113260

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File numbers found in text: 333-226038

Date
April 24, 2019
Author
Christopher B. Primiano
Form
CORRESP
Company
Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)

Letter

KARYOPHARM THERAPEUTICS INC.

85 WELLS AVENUE, SECOND FLOOR

NEWTON, MA 02459

April 22,

Via EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Re: Karyopharm Therapeutics Inc.

Post-Effective Amendment No. 2 to Form S-3 Registration Statement

File No. 333-226038

Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Karyopharm Therapeutics Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Post-Effective Amendment No. 2 to Form S-3 Registration Statement (File No. 333-226038), so that it may become effective at 4:00 p.m. Eastern time on April 24, 2019, or as soon thereafter as practicable.

Very truly yours,
Karyopharm Therapeutics Inc.

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CORRESP
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CORRESP

 KARYOPHARM THERAPEUTICS INC.

85 WELLS AVENUE, SECOND FLOOR

NEWTON, MA 02459

 April 22,
2019

 Via EDGAR

 Securities and Exchange Commission

 Division of Corporation Finance

 100 F Street, N.E.

Washington, D.C. 20549

Re:
 Karyopharm Therapeutics Inc.

 Post-Effective Amendment No. 2 to Form S-3 Registration Statement

 File No. 333-226038

 Request for Acceleration

Ladies and Gentlemen:

 Pursuant to Rule 461 promulgated
under the Securities Act of 1933, as amended, Karyopharm Therapeutics Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Post-Effective Amendment No. 2 to Form
S-3 Registration Statement (File No. 333-226038), so that it may become effective at 4:00 p.m. Eastern time on April 24, 2019, or as soon thereafter as
practicable.

 Very truly yours,

Karyopharm Therapeutics Inc.

By:

/s/ Christopher B. Primiano

 Name:

 Title:

 Christopher B. Primiano

 Executive Vice
President, Chief Business Officer, General Counsel and Secretary