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SEC Company Response from SYNLOGIC, INC. (SYBX) (CIK 0001527599) (SYBX) — Aug 28, 2018

SYNLOGIC, INC. (SYBX) (CIK 0001527599)
Date: Aug. 28, 2018 · CIK: 0001527599 · Accession: 0001193125-18-260576

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File numbers found in text: 333-226730

Date
August 28, 2018
Author
Aoife M. Brennan
Form
CORRESP
Company
SYNLOGIC, INC. (SYBX) (CIK 0001527599)

Letter

SYNLOGIC, INC.

301 Binney Street, Suite 402

Cambridge, Massachusetts 02142

August 28, 2018

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Ms. Mary Beth Breslin

Ms. Irene Paik

Re: Synlogic, Inc.

Registration Statement on Form S-3

Filed August 9, 2018, as amended on August 23, 2018

File No. 333-226730 (the “Registration Statement”)

Acceleration Request

Ladies and Gentlemen:

In accordance with Rule 461 of Regulation C promulgated under the Securities Act of 1933, as amended, Synlogic, Inc. (the “Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Thursday, August 30, 2018, at 4:00 p.m., Eastern Time, or as soon as thereafter practicable.

The Registrant hereby authorizes Matthew J. Gardella of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, to orally modify or withdraw this request for acceleration on its behalf. The Registrant hereby acknowledges its responsibilities under the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended, as they relate to the proposed public offering of the securities specified in the Registration Statement.

The cooperation of the staff in meeting the timetable described above is very much appreciated.

Please contact Matthew J. Gardella of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. at (617) 348-1735 with any questions regarding this request.

Very truly yours,
SYNLOGIC, INC.

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CORRESP
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CORRESP

 SYNLOGIC, INC.

301 Binney Street, Suite 402

Cambridge, Massachusetts 02142

August 28, 2018

 VIA EDGAR

U.S. Securities and Exchange Commission

 Division of Corporation
Finance

 100 F Street, N.E.

 Washington, D.C. 20549

Attention:
 Ms. Mary Beth Breslin

 Ms. Irene Paik

Re:
 Synlogic, Inc.

 Registration Statement on Form S-3

 Filed August 9, 2018, as amended on August 23, 2018

 File No. 333-226730 (the “Registration Statement”)

 Acceleration Request

Ladies and Gentlemen:

 In accordance with Rule 461 of
Regulation C promulgated under the Securities Act of 1933, as amended, Synlogic, Inc. (the “Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced
Registration Statement to Thursday, August 30, 2018, at 4:00 p.m., Eastern Time, or as soon as thereafter practicable.

 The Registrant hereby
authorizes Matthew J. Gardella of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, to orally modify or withdraw this request for acceleration on its behalf. The Registrant hereby acknowledges its responsibilities
under the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended, as they relate to the proposed public offering of the securities specified in the Registration Statement.

The cooperation of the staff in meeting the timetable described above is very much appreciated.

Please contact Matthew J. Gardella of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. at (617) 348-1735 with
any questions regarding this request.

 Very truly yours,

SYNLOGIC, INC.

/s/ Aoife M. Brennan

 Aoife M. Brennan

 Interim President, Chief
Executive Officer and Chief Medical Officer

cc:
 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

 Matthew J. Gardella, Esq.