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SEC Company Response from OnKure Therapeutics, (OKUR) — Apr 30, 2026

OnKure Therapeutics, Inc.
Date: April 30, 2026 · CIK: 0001637715 · Accession: 0001193125-26-197156

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File numbers found in text: 333-295304

Date
May 4, 2026
Author
Nicholas A. Saccomano
Form
CORRESP
Company
OnKure Therapeutics, Inc.

Letter

Re:

OnKure Therapeutics, Inc. 6707 Winchester Circle, Suite 400 Boulder, Colorado 80301 April 30, 2026 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Chris Edwards

OnKure Therapeutics, Inc.

Registration Statement on Form S-3

File No. 333-295304

Acceleration Request

Requested Date:

May 4, 2026

Requested Time:

4:00 p.m. Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as amended, OnKure Therapeutics, Inc. (the “ Company ”) hereby requests that the above-referenced Registration Statement on Form S-3 (File No. 333-295304) (the “ Registration Statement ”) be declared effective at the “Requested Date” and “Requested Time” set forth above, or as soon thereafter as practicable, or at such later time as the Company or its counsel may orally request via telephone call to the staff of the Division of Corporation Finance of the Securities and Exchange Commission. Once the Registration Statement has been declared effective, please orally confirm that event with the Company’s counsel, Wilson Sonsini Goodrich & Rosati, P.C., by calling Phillip S. McGill at (858) 350-2249. [ Signature page follows ]

Sincerely,
OnKure Therapeutics, Inc.

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CORRESP
 1
 filename1.htm

 CORRESP

 OnKure Therapeutics, Inc.
 6707 Winchester Circle, Suite 400
 Boulder, Colorado 80301 April 30,
2026 VIA EDGAR U.S. Securities and Exchange
Commission Division of Corporation Finance
 100 F Street, N.E. Washington, D.C. 20549
 Attention: Chris Edwards

    

 Re:

 OnKure Therapeutics, Inc.

 Registration Statement on Form S-3

 File No. 333-295304

 Acceleration Request

    Requested Date:

 May 4, 2026

    Requested Time:

 4:00 p.m.
 Ladies and Gentlemen:
 Pursuant to Rule 461 under the Securities Act of 1933, as amended, OnKure Therapeutics, Inc.
(the “ Company ”) hereby requests that the above-referenced Registration Statement on Form S-3 (File No. 333-295304) (the
“ Registration Statement ”) be declared effective at the “Requested Date” and “Requested Time” set forth above, or as soon thereafter as practicable, or at such later time as the Company or its counsel may
orally request via telephone call to the staff of the Division of Corporation Finance of the Securities and Exchange Commission. Once the Registration Statement has been declared effective, please orally confirm that event with the Company’s
counsel, Wilson Sonsini Goodrich & Rosati, P.C., by calling Phillip S. McGill at (858) 350-2249.
 [ Signature page follows ]

 Sincerely,

 OnKure Therapeutics, Inc.

 /s/ Nicholas A. Saccomano

 Nicholas A. Saccomano

 Chief Executive Officer

 cc:
 Phillip S. McGill, Wilson Sonsini Goodrich & Rosati, P.C.