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    K&L Gates LLP

    Hearst
    Tower, 47th Floor

    214
    North Tryon Street

    Charlotte,
    NC 28202

    T
    +1 704 331 7400    F +1 704 331 7598

    klgates.com

    December 4, 2017

VIA EDGAR CORRESPONDENCE

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street N.E.

Washington, D.C. 20549

 Attn: Irene Paik

 Re: Cue Biopharma, Inc.

Registration Statement on Form S-1

Filed September 21, 2017

File No. 333-220550

Dear Ms. Paik:

On behalf of Cue Biopharma, Inc. (the “Company”),
we submit this letter providing a response to the comments raised by the Staff of the Securities and Exchange Commission (the “Staff”)
on November 30, 2017 with respect to the Company’s registration statement on Form S-1 (File No. 333-220550) (the “Registration
Statement”). Simultaneously with the filing of this letter, the Company is filing by EDGAR Amendment No. 3 to the Registration
Statement (the “Registration Statement Amendment”) responding to the Staff’s comments as noted below. The bold
type below is the Staff’s comments and the regular type constitutes the Company’s responses thereto.

The Offering,
page 12

 1. Please expand the discussion of the escrow account to clarify that the funds will not be released
from escrow until you secure the listing on the Nasdaq Capital Market and that all funds will be returned to investors if you are
unable to secure the listing.

Revised disclosure responding
to this comment has been added on the cover page and pages 11,  12 and 32 of the Registration Statement Amendment.

 Business

Our Collaboration
Agreement with Merck, page 58

 2. We note your agreement with Merck required you to "forebear from researching, developing or
licensing to a third party rights related to any Cue Biologics drug candidate for the treatment of autoimmune disease." Please
revise the disclosure throughout your filing to clarify how this provision impacts your current operations and your strategic plans.
For example:

U.S. Securities and Exchange Commission

December 4, 2017

Page 2

 • On page 1 you indicate you are "developing a novel and proprietary class of biologic drugs
...to treat a broad range of cancers and autoimmune disorders."

 • On page 2 in the discussion of your approach for next generation immunotherapies, you discuss Type
1 diabetes, celiac disease, arthritis and other autoimmune diseases.

 • On page 3, you state that you are expanding your technology to "generate highly promising
and novel immunotherapeutics for the treatment of debilitating autoimmune disorders."

 • On page 41, you indicate that you intend to use proceeds from the offering to "optimize drug
scaffold for the treatment of autoimmune indications...".

Revised disclosure responding
to this comment has been added on pages 6, 8, 19, 50, 53 and 55 of the Registration
Statement Amendment.

 3. Please revise your description of the Collaboration Agreement with Merck to provide the following
information:

 • the duration of the agreement and royalty term;

 • your rights and performance obligations under the agreement;

 • termination provisions;

 • up-front payment to be received;

 • whether the up-front payment is refundable or not;

 • aggregate future potential milestone payment to be received for each of the research, development,
regulatory and/or commercial milestone categories, if applicable; and

 • royalty rates or a royalty range within a ten-percent range if confidential treatment is requested.

Please also file the Collaboration
Agreement as an exhibit to your registration statement. Alternatively, please provide us with an analysis supporting your determination
that the agreement is not a required exhibit. See Item 601(b)(10) of Regulation S-K.

Revised disclosure responding
to this comment has been added on pages 55 and 56 of the Registration Statement Amendment. In addition, the Collaboration
has been filed with the Registration Statement Amendment as Exhibit No. 10.21.

We appreciate your time
and attention to the Company’s responses to the Staff’s comments. Should you have any questions, please call me at
(704) 331-7440.

U.S. Securities and Exchange Commission

December 4, 2017

Page 3

    Very truly yours,

    /s/ Mark Busch

    Mark Busch

 cc: Daniel Passeri, Chief Executive Officer

Gary Schuman, Chief Financial
Officer