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CORRESP Filing

Ensysce Biosciences, Inc.
Date: April 14, 2026 · CIK: 0001716947 · Accession: 0001493152-26-016449

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File numbers found in text: 333-294939

Date
April 14, 2026
Author
President
Form
CORRESP
Company
Ensysce Biosciences, Inc.

Letter

Ensysce Biosciences, Inc.

Ivanhoe Avenue, Suite 201

La Jolla, California 92037

April 14, 2026

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

F Street, NE

Washington, D.C. 20549

Attention: Alan Campbell, Esq.

Re: Ensysce Biosciences, Inc.

Registration Statement on Form S-3

SEC File No. 333-294939

Filed April 9, 2026

Ladies and Gentlemen:

Pursuant to Rule 461 of Regulation C of the General Rules and Regulations under the Securities Act of 1933, as amended, Ensysce Biosciences, Inc. hereby requests that the effective date of the above-referenced Registration Statement be accelerated to 10:00 AM, Eastern Time, on April 15, 2026, or as soon thereafter as is practicable, or at such other time thereafter as our counsel, Troutman Pepper Locke LLP, may request by telephone. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Troutman Pepper Locke LLP, by calling Gregory Rubis at (609) 951-4105.

Please direct any questions or comments concerning this request to Gregory Rubis.

ENSYSCE BIOSCIENCES, Inc.

By:

/s/ Lynn Kirkpatrick

Name: Dr. Lynn Kirkpatrick

Title: President and Chief Executive Officer

cc:

Eric D. Kline, Troutman Pepper Locke LLP

Gregory Rubis, Troutman Pepper Locke LLP

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CORRESP
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filename1.htm

Ensysce
Biosciences, Inc.

7946
Ivanhoe Avenue, Suite 201

La
Jolla, California 92037

April
14, 2026

VIA
EDGAR

U.S.
Securities and Exchange Commission

Division
of Corporation Finance

Office
of Life Sciences

100
F Street, NE

Washington,
D.C. 20549

Attention:
Alan Campbell, Esq.

    Re:
    Ensysce
    Biosciences, Inc.

    Registration
    Statement on Form S-3

    SEC
    File No. 333-294939

    Filed
    April 9, 2026

Ladies
and Gentlemen:

Pursuant
to Rule 461 of Regulation C of the General Rules and Regulations under the Securities Act of 1933, as amended, Ensysce Biosciences, Inc.
hereby requests that the effective date of the above-referenced Registration Statement be accelerated to 10:00 AM, Eastern Time, on April
15, 2026, or as soon thereafter as is practicable, or at such other time thereafter as our counsel, Troutman Pepper Locke LLP, may request
by telephone. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Troutman
Pepper Locke LLP, by calling Gregory Rubis at (609) 951-4105.

Please
direct any questions or comments concerning this request to Gregory Rubis.

    ENSYSCE
    BIOSCIENCES, Inc.

    By:

    /s/
    Lynn Kirkpatrick

    Name:
    Dr.
    Lynn Kirkpatrick

    Title:
    President
    and Chief Executive Officer

    cc:

    Eric
    D. Kline, Troutman Pepper Locke LLP

    Gregory
    Rubis, Troutman Pepper Locke LLP