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CORRESP Filing

NEONC TECHNOLOGIES HOLDINGS, INC.
Date: April 7, 2026 · CIK: 0001979414 · Accession: 0001829126-26-003266

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File numbers found in text: 333-294845

Date

April 7, 2026

Author

NEONC

Form

CORRESP

Company

NEONC TECHNOLOGIES HOLDINGS, INC.

Letter

NEONC TECHNOLOGIES HOLDINGS, INC.

Park Sorrento, Suite 205

Calabasas, CA 91302

April 7, 2026

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

F Street, N.E.

Washington, DC 20549

Re: NEONC TECHNOLOGIES HOLDINGS, INC.

Registration Statement on Form S-3 (File No. 333-294845) (the “Registration Statement”)

Acceleration Request

Ladies and Gentlemen:

NeOnc Technologies Holdings, Inc. hereby requests that the effectiveness under the Securities Act of 1933, as amended, of the above-captioned Registration Statement on Form S-3, be accelerated to 4:30 p.m., Eastern Time, on April 9, 2026, or as soon thereafter as practicable.

Please notify Thomas Poletti at (714) 371-2501 or Veronica Lah at (310) 312-4130 of Manatt, Phelps & Phillips, LLP as soon as possible as to the time the Registration Statement has been declared effective pursuant to this acceleration request. We appreciate your assistance and cooperation in this matter.

Sincerely,
NEONC
TECHNOLOGIES HOLDINGS, INC.

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CORRESP
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filename1.htm

NEONC
TECHNOLOGIES HOLDINGS, INC.

23975
Park Sorrento, Suite 205

Calabasas,
CA 91302

April
7, 2026

VIA
EDGAR

U.S.
Securities and Exchange Commission

Division
of Corporation Finance

100
F Street, N.E.

Washington,
DC 20549

    Re:
    NEONC
    TECHNOLOGIES HOLDINGS, INC.

Registration
Statement on Form S-3 (File No. 333-294845) (the “Registration Statement”)

Acceleration
Request

Ladies
and Gentlemen:

NeOnc
Technologies Holdings, Inc. hereby requests that the effectiveness under the Securities Act of 1933, as amended, of the above-captioned
Registration Statement on Form S-3, be accelerated to 4:30 p.m., Eastern Time, on April 9, 2026, or as soon thereafter as practicable.

Please
notify Thomas Poletti at (714) 371-2501 or Veronica Lah at (310) 312-4130 of Manatt, Phelps & Phillips, LLP as soon as possible as
to the time the Registration Statement has been declared effective pursuant to this acceleration request. We appreciate your assistance
and cooperation in this matter.

    Sincerely,

    NEONC
    TECHNOLOGIES HOLDINGS, INC.

    By:
    /s/
    Amir Heshmatpour

    Name:
    Amir Heshmatpour

    Title:
    Chief Executive
    Officer and President