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CORRESP Filing

NEONC TECHNOLOGIES HOLDINGS, INC.
Date: April 14, 2026 · CIK: 0001979414 · Accession: 0001829126-26-003500

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File numbers found in text: 333-294999

Date

April 14, 2026

Author

NEONC

Form

CORRESP

Company

NEONC TECHNOLOGIES HOLDINGS, INC.

Letter

NEONC TECHNOLOGIES HOLDINGS, INC.

Park Sorrento, Suite 205

Calabasas, CA 91302

April 14, 2026

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

F Street, N.E.

Washington, DC 20549

Re: NEONC TECHNOLOGIES HOLDINGS, INC.

Registration Statement on Form S-3 (File No. 333-294999) (the "Registration Statement")

Acceleration Request

Ladies and Gentlemen:

NeOnc Technologies Holdings, Inc. hereby requests that the effectiveness under the Securities Act of 1933, as amended, of the above-captioned Registration Statement on Form S-3, be accelerated to 4:30 p.m., Eastern Time, on April 16, 2026, or as soon thereafter as practicable.

Please notify Thomas Poletti at (714) 371-2501 or Veronica Lah at (310) 312-4130 of Manatt, Phelps & Phillips, LLP as soon as possible as to the time the Registration Statement has been declared effective pursuant to this acceleration request. We appreciate your assistance and cooperation in this matter.

Sincerely,
NEONC
TECHNOLOGIES HOLDINGS, INC.

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CORRESP
 1
 filename1.htm

 NEONC
TECHNOLOGIES HOLDINGS, INC.

 23975
Park Sorrento, Suite 205

 Calabasas,
CA 91302

 April
14, 2026

 VIA
EDGAR

 U.S.
Securities and Exchange Commission

 Division
of Corporation Finance

 100
F Street, N.E.

 Washington,
DC 20549

 Re:
 NEONC
 TECHNOLOGIES HOLDINGS, INC.

 Registration
Statement on Form S-3 (File No. 333-294999) (the "Registration Statement")

 Acceleration
Request

 Ladies
and Gentlemen:

 NeOnc Technologies Holdings, Inc. hereby requests that the effectiveness
under the Securities Act of 1933, as amended, of the above-captioned Registration Statement on Form S-3, be accelerated to 4:30 p.m.,
Eastern Time, on April 16, 2026, or as soon thereafter as practicable.

 Please notify Thomas Poletti at (714) 371-2501 or Veronica Lah at (310)
312-4130 of Manatt, Phelps & Phillips, LLP as soon as possible as to the time the Registration Statement has been declared effective
pursuant to this acceleration request. We appreciate your assistance and cooperation in this matter.

 Sincerely,

 NEONC
 TECHNOLOGIES HOLDINGS, INC.

 By:
 /s/
 Amir Heshmatpour

 Name:
 Amir Heshmatpour

 Title:
 Chief Executive
 Officer and President