CORRESP Filing
ASSEMBLY BIOSCIENCES, INC.
Date: Nov. 19, 2025 · CIK: 0001426800 · Accession: 0001193125-25-288088
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File numbers found in text: 333-290866
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CORRESP 1 filename1.htm CORRESP November 19, 2025 Via EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Assembly Biosciences, Inc. Registration Statement on Form S-3 Filed October 14, 2025 File No. 333-290866 Request for Acceleration of Effective Date Ladies and Gentlemen: Pursuant to Rule 461 of the Securities Act of 1933, as amended, Assembly Biosciences, Inc. (the “Company”) hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-290866) (the “Registration Statement”) to 4:30 p.m. Eastern Time on Friday, November 21, 2025 or as soon thereafter as practicable. The Company acknowledges that both the Company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff of the U.S. Securities and Exchange Commission. Please contact P. Michelle Gasaway of Skadden, Arps, Slate, Meagher & Flom LLP, special counsel to the Company, at +1.213.687.5122 as soon as the Registration Statement has been declared effective or if you have any other questions or concerns regarding this matter. Regards, By: /s/ John O. Gunderson Name: John O. Gunderson Title: VP, General Counsel and Corporate Secretary cc: P. Michelle Gasaway Skadden, Arps, Slate, Meagher & Flom LLP Jason A. Okazaki Assembly Biosciences, Inc. Two Tower Place, 7th Floor, South San Francisco, CA 94080