SEC Company Response from Silence Therapeutics (SLN) — Dec 31, 2025
Silence Therapeutics plc
Date: Dec. 31, 2025 · CIK: 0001479615 · Accession: 0001193125-25-338311
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File numbers found in text: 001-39487
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CORRESP 1 filename1.htm CORRESP 12 Hammersmith Grove London, W6 7AP United Kingdom Tel: +44 (0) 203 457 6900 Division of Corporate Finance Office of Life Sciences Attention: Vanessa Robertson, Kevin Vaughn United States Securities and Exchange Commission Washington, D.C. 20549 December 22, 2025 Re: Silence Therapeutics plc Form 10-K for the fiscal year ended December 31, 2024 File No. 001-39487 Dear Vanessa Robertson: We have reviewed your letter requesting further disclosure of research and development expenses on a program-by-program basis for our development programs. As requested, we will further break out research and disclosure expenses on a program-by-program basis for our clinical development candidates. We will include this additional disclosure in Management’s Discussion and Analysis of Financial Condition and Results of Operation when we report our next Form 10-K for fiscal year ended December 31, 2025. Sincerely, /s/ Rhonda Hellums Rhonda Hellums Chief Financial Officer Silence Therapeutics plc Silence Therapeutics Plc. Company number 02992058, Registered in England Registered Office: 27 Eastcastle Street, London, W1W 8DH. VAT number: GB 567 158 11 Confidential data (L2). Printed copies are uncontrolled and must be destroyed after use.