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CORRESP Filing

Jaguar Health, Inc.
Date: July 28, 2025 · CIK: 0001585608 · Accession: 0001193125-25-166543

Offering / Registration Process

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File numbers found in text: 333-288927

Date
July 28, 2025
Author
Lisa A. Conte
Form
CORRESP
Company
Jaguar Health, Inc.

Letter

Re: Jaguar Health, Inc. Registration Statement on Form S-3 File No. 333-288927 Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Jaguar Health, Inc., a Delaware corporation (the “ Registrant ”), hereby requests the above-referenced Registration Statement on Form S-3 (the “ Registration Statement ”) be declared effective by the Securities and Exchange Commission on Wednesday, July 30, 2025, at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable. The Registrant hereby authorizes each of Donald C. Reinke, Esq. and Michael S. Lee, Esq. of Reed Smith LLP, attorneys for the Registrant, to orally modify or withdraw this request for acceleration. Please confirm effectiveness by advising our counsel, Michael S. Lee of Reed Smith LLP, at (212) 549-0358.

July 28, 2025 Via EDGAR U.S. Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549

Very truly yours,
Jaguar Health, Inc.

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CORRESP
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 CORRESP

 July 28, 2025
 Via EDGAR U.S. Securities and Exchange Commission
 100 F Street, N.E. Washington, D.C. 20549

 Re:
 Jaguar Health, Inc.
 Registration Statement on Form S-3
 File No. 333-288927
 Ladies and Gentlemen: Pursuant to Rule 461
promulgated under the Securities Act of 1933, as amended, Jaguar Health, Inc., a Delaware corporation (the “ Registrant ”), hereby requests the above-referenced Registration Statement on Form
 S-3 (the “ Registration Statement ”) be declared effective by the Securities and Exchange Commission on Wednesday, July 30, 2025, at 4:00 p.m., Eastern Time, or as soon thereafter as is
practicable. The Registrant hereby authorizes each of Donald C. Reinke, Esq. and Michael S. Lee, Esq. of Reed Smith LLP, attorneys for
the Registrant, to orally modify or withdraw this request for acceleration. Please confirm effectiveness by advising our counsel, Michael
S. Lee of Reed Smith LLP, at (212) 549-0358.

 Very truly yours,

 Jaguar Health, Inc.

 /s/ Lisa A. Conte

 Lisa A. Conte

 Chief Executive Officer and President
 Jaguar Health, Inc. • 200 Pine Street, Suite 400 • San Francisco, CA 94104
 Tel : +1 (415) 371-8300 • Fax: +1 (415)
 371-8311 • https://jaguar.health