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CORRESP Filing

Jaguar Health, Inc.
Date: Nov. 24, 2025 · CIK: 0001585608 · Accession: 0001193125-25-293735

Offering / Registration Process

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File numbers found in text: 333-290702

Date
November 24, 2025
Author
Lisa A. Conte
Form
CORRESP
Company
Jaguar Health, Inc.

Letter

November 24, 2025 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Re: Jaguar Health, Inc. Registration Statement on Form S-3 File No. 333-290702 Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Jaguar Health, Inc., a Delaware corporation (the “ Registrant ”), hereby requests the above-referenced Registration Statement on Form S-3 (the “ Registration Statement ”) be declared effective by the Securities and Exchange Commission on Tuesday, November 25, 2025, at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable. The Registrant hereby authorizes each of Donald C. Reinke, Esq. and Michael S. Lee, Esq. of Reed Smith LLP, attorneys for the Registrant, to orally modify or withdraw this request for acceleration. Please confirm effectiveness by advising our counsel, Michael S. Lee of Reed Smith LLP, at (212) 549-0358. Very truly yours, Jaguar Health, Inc. /s/ Lisa A. Conte Lisa A. Conte Chief Executive Officer and President Jaguar Health, Inc. • 200 Pine Street, Suite 400 • San Francisco, CA 94104 Tel : +1 (415) 371-8300 • Fax: +1 (415) 371-8311 • https://jaguar.health

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CORRESP
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 CORRESP

 November 24, 2025   Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549   Re: Jaguar Health, Inc. Registration Statement on Form S-3 File No. 333-290702   Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Jaguar Health, Inc., a Delaware corporation (the “ Registrant ”), hereby requests the above-referenced Registration Statement on Form S-3 (the “ Registration Statement ”) be declared effective by the Securities and Exchange Commission on Tuesday, November 25, 2025, at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable. The Registrant hereby authorizes each of Donald C. Reinke, Esq. and Michael S. Lee, Esq. of Reed Smith LLP, attorneys for the Registrant, to orally modify or withdraw this request for acceleration. Please confirm effectiveness by advising our counsel, Michael S. Lee of Reed Smith LLP, at (212) 549-0358.   Very truly yours, Jaguar Health, Inc.   /s/ Lisa A. Conte Lisa A. Conte Chief Executive Officer and President
 Jaguar Health, Inc. • 200 Pine Street, Suite 400 • San Francisco, CA 94104 Tel : +1 (415) 371-8300 • Fax: +1 (415) 371-8311 • https://jaguar.health