CORRESP Filing
SOPHiA GENETICS SA (SOPH) (CIK 0001840706)
Date: Aug. 13, 2025 · CIK: 0001840706 · Accession: 0000950103-25-010241
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File numbers found in text: 333-289270
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CORRESP 1 filename1.htm August 13, 2025 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: SOPHiA GENETICS SA Registration Statement on Form F-3 Registration No. 333-289270 Ladies and Gentlemen: In accordance with Rule 461 under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the Registration Statement on Form F-3 (File No. 333-289270) (as amended, the "Registration Statement") of SOPHiA GENETICS SA. We respectfully request that the Registration Statement be declared effective as of 4:00 p.m., Eastern time, on August 15, 2025 or as soon as practicable thereafter. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Davis Polk & Wardwell LLP, by calling Sierra Acosta at (212) 450-3504. Thank you for your assistance in this matter. Sincerely, SOPHiA GENETICS SA By: /s/ Daan van Well Name: Daan van Well Title: Chief Legal & Regulatory Officer