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CORRESP Filing

SOPHiA GENETICS SA (SOPH) (CIK 0001840706)
Date: March 4, 2026 · CIK: 0001840706 · Accession: 0000950103-26-003212

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File numbers found in text: 333-293970

Date
March 4, 2026
Author
SOPHiA GENETICS SA
Form
CORRESP
Company
SOPHiA GENETICS SA (SOPH) (CIK 0001840706)

Letter

Re: SOPHiA GENETICS SA

March 4, 2026

VIA EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Registration Statement on Form F-3

Registration No. 333-293970

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the Registration Statement on Form F-3 (File No. 333-293970) (as amended, the “Registration Statement”) of SOPHiA GENETICS SA. We respectfully request that the Registration Statement be declared effective as of 4:00 p.m., Eastern time, on March 6, 2026 or as soon as practicable thereafter.

Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Davis Polk & Wardwell LLP, by calling Sierra Acosta at (212) 450-3504.

Thank you for your assistance in this matter.

Sincerely,
SOPHiA GENETICS SA

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CORRESP
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filename1.htm

    March 4, 2026

    VIA EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

    Re:
    SOPHiA GENETICS SA

Registration Statement on Form F-3

Registration No. 333-293970

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended,
we hereby request acceleration of the effective date of the Registration Statement on Form F-3 (File No. 333-293970) (as amended, the
“Registration Statement”) of SOPHiA GENETICS SA. We respectfully request that the Registration Statement be declared effective
as of 4:00 p.m., Eastern time, on March 6, 2026 or as soon as practicable thereafter.

Once the Registration Statement has been declared effective, please
orally confirm that event with our counsel, Davis Polk & Wardwell LLP, by calling Sierra Acosta at (212) 450-3504.

Thank you for your assistance in this matter.

Sincerely,

    SOPHiA GENETICS SA

    By:
    /s/ Daan van Well

    Name:
    Daan van Well

    Title:
    Chief Legal & Regulatory Officer