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SEC Comment Letter 0000000000-25-011805 to Aprea Therapeutics, Inc. (APRE)

Aprea Therapeutics, Inc.
Date: Dec. 23, 2025 · CIK: 0001781983 · Accession: 0000000000-25-011805

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File numbers found in text: 333-292286

Date
December 23, 2025
Author
Oren Gilad, Ph.D.
Form
UPLOAD
Company
Aprea Therapeutics, Inc.

Letter

December 23, 2025 Oren Gilad, Ph.D. President and Chief Executive Officer Aprea Therapeutics, Inc. 3805 Old Easton Road Doylestown, PA 18902 Re:Aprea Therapeutics, Inc. Registration Statement on Form S-3 Filed December 19, 2025 File No. 333-292286 Dear Oren Gilad Ph.D.: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Chris Edwards at 202-551-6761 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc:Patrick O’Malley, Esq.

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December 23, 2025
Oren Gilad, Ph.D.
President and Chief Executive Officer
Aprea Therapeutics, Inc.
3805 Old Easton Road
Doylestown, PA 18902
Re:Aprea Therapeutics, Inc.
Registration Statement on Form S-3
Filed December 19, 2025
File No. 333-292286
Dear Oren Gilad Ph.D.:
            This is to advise you that we have not reviewed and will not review your registration
statement.
            Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you
that the company and its management are responsible for the accuracy and adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action by the staff.
            Please contact Chris Edwards at 202-551-6761 with any questions.
Sincerely,
Division of Corporation Finance
Office of Life Sciences
cc:Patrick O’Malley, Esq.