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CORRESP Filing

Aprea Therapeutics, Inc.
Date: April 27, 2026 · CIK: 0001781983 · Accession: 0001104659-26-049298

Offering / Registration Process

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File numbers found in text: 333-295247

Date
April 27, 2026
Author
Oren Gilad
Form
CORRESP
Company
Aprea Therapeutics, Inc.

Letter

APREA THERAPEUTICS, INC.

3805 Old Easton Road

Doylestown, PA 18902

April 27, 2026

VIA EDGAR

Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attention: Doris Stacey Gama

Re: Aprea Therapeutics, Inc.

Registration Statement on Form S-3

File No. 333-295247

Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Aprea Therapeutics, Inc. (the " Registrant ") hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-295247), so that it may become effective at 5:00 p.m. Eastern Time on April 29, 2026, or as soon as practicable thereafter, or at such later time as the Registrant or its counsel may orally request via telephone call to the staff.

The cooperation of the staff in meeting the timetable described above is very much appreciated.

Please call Patrick O'Malley, Esq. of DLA Piper LLP (US), counsel to the Company, at (206) 839-4831, with any comments or questions regarding the Registration Statement.

Very truly yours,
APREA THERAPEUTICS, INC.

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CORRESP
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 filename1.htm

 APREA THERAPEUTICS,
INC.

 3805 Old Easton Road

 Doylestown, PA 18902

 April 27, 2026

 VIA EDGAR

 Securities and Exchange Commission

 Division of Corporation Finance

 Office of Life Sciences

 100 F Street, N.E.

 Washington, D.C. 20549

 Attention: Doris Stacey Gama

 Re:
 Aprea Therapeutics, Inc.

 Registration Statement on Form S-3

 File No. 333-295247

 Request for Acceleration

 Ladies and Gentlemen:

 Pursuant
to Rule 461 promulgated under the Securities Act of 1933, as amended, Aprea Therapeutics, Inc. (the " Registrant ") hereby
requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-295247), so
that it may become effective at 5:00 p.m. Eastern Time on April 29, 2026, or as soon as practicable thereafter, or at such later time
as the Registrant or its counsel may orally request via telephone call to the staff.

 The
cooperation of the staff in meeting the timetable described above is very much appreciated.

 Please
call Patrick O'Malley, Esq. of DLA Piper LLP (US), counsel to the Company, at (206) 839-4831, with any comments or questions
regarding the Registration Statement.

 Very truly yours,

 APREA THERAPEUTICS, INC.

 By:
 /s/ Oren Gilad

 Name:
 Oren Gilad

 Title:
 Chief Executive Officer

 cc:
 Fahd Riaz, Esq., DLA Piper LLP (US)

 Dylan Caplan, Esq., DLA Piper LLP (US)