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Correspondence 0001104659-26-029722 from Aprea Therapeutics, Inc. (APRE)

Aprea Therapeutics, Inc.
Date: March 17, 2026 · CIK: 0001781983 · Accession: 0001104659-26-029722

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File numbers found in text: 333-293609

Date
March 17, 2026
Author
John Hamill
Form
CORRESP
Company
Aprea Therapeutics, Inc.

Letter

APREA THERAPEUTICS, INC.

3805 Old Easton Road

Doylestown, PA 18902

March 17, 2026

VIA EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Alan Campbell

Re: Aprea Therapeutics, Inc.

Registration Statement on Form S-3

File No. 333-293609

Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Aprea Therapeutics, Inc. (the " Registrant ") hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-293609), so that it may become effective at 5:00 p.m. Eastern Time on March 19, 2026, or as soon as practicable thereafter, or at such later time as the Registrant or its counsel may orally request via telephone call to the staff.

The cooperation of the staff in meeting the timetable described above is very much appreciated.

Please call Patrick O'Malley, Esq. of DLA Piper LLP (US), counsel to the Company, at (206) 839-4831, with any comments or questions regarding the Registration Statement.

Very truly yours,
APREA THERAPEUTICS, INC.

Show Raw Text
CORRESP
 1
 filename1.htm

 APREA THERAPEUTICS,
INC.

 3805 Old Easton Road

 Doylestown, PA 18902

 March 17, 2026

 VIA EDGAR

 Securities and Exchange Commission

 Division of Corporation Finance

 100 F Street, N.E.

 Washington, D.C. 20549

 Attention: Alan Campbell

 Re:
 Aprea Therapeutics, Inc.

 Registration Statement on Form S-3

 File No. 333-293609

 Request for Acceleration

 Ladies and Gentlemen:

 Pursuant
to Rule 461 promulgated under the Securities Act of 1933, as amended, Aprea Therapeutics, Inc. (the " Registrant ")
hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-293609), so
that it may become effective at 5:00 p.m. Eastern Time on March 19, 2026, or as soon as practicable thereafter, or at such later time
as the Registrant or its counsel may orally request via telephone call to the staff.

 The
cooperation of the staff in meeting the timetable described above is very much appreciated.

 Please
call Patrick O'Malley, Esq. of DLA Piper LLP (US), counsel to the Company, at (206) 839-4831, with any comments or questions
regarding the Registration Statement.

 Very truly yours,

 APREA THERAPEUTICS, INC.

 By:
 /s/
 John Hamill

 Name:
 John Hamill

 Title:
 Senior Vice President
 and Chief Financial Officer

 cc:
 Fahd Riaz, Esq., DLA Piper LLP (US)

 Dylan Caplan, Esq., DLA Piper LLP (US)